Revealing Prognostic Markers for Small Cell Lung Cancer

In a new study, a research team led by Professor Zhang Peng of the Shanghai Lung Hospital affiliated with Tongji University, China, Professor Zhou Hu of the Chinese Academy of Sciences Shanghai Institute of Materia Medica, Professor Gao Daming and Ji Hongbin of the Molecular Cell Science Innovation Center of the Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology has reported for the first time a large-scale…

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Protein IKAROS Regulates the Development of B Cells

The nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into complex three-dimensional structures that support the function of its coding regions. This arrangement is crucial for cell development, but the specific steps for different types of cells vary greatly. Establishing correct communication between genes and distant control switches in the right cells at the right time is not an easy task. In fact, few…

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Scientists Have Screened New Serotonin Transporter Inhibitors From Over 20 Billion Molecules

Highlights •Large-library docking finds conformationally and target-selective SERT inhibitors •Cryo-EM supports the computationally predicted structure •The inhibitors are anti-depressant-like and alleviate opioid withdrawal in mice •Targeting of transporters for structure-based ligand discovery   5-hydroxytryptamine transporter (SERT) is a common target for antidepressants as it can “transport” serotonin from synapses.   Transporting protein transporters is a process of “swallowing and vomiting”, completed by alternating protein conformations opening outward and inward. Research…

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The Base Editor Is Expected to Be Used for the Treatment of CD3Δ Severe Combined Immunodeficiency

In a new study, researchers from research institutions such as the University of California, Los Angeles, discovered that advanced genome editing technology may be able to be used for a rare and fatal genetic disease, D3 delta severe combined immunodeficiency, CD3δ SCID, for a one-time treatment. The relevant research results were published online in Cell, with the title “Human T cell generation is restored in CD3δ severe combined immunodeficiency through…

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Restoring lost epigenetic information can make aging mammals rejuvenate

An international study lasting for 13 years has shown for the first time that the degradation of the way DNA is assembled and regulated – the so-called epigenetics – can drive the aging of organisms, and has nothing to do with the change of the genetic code itself. This study shows that the destruction of epigenetic information leads to the aging of mice, and the restoration of the integrity of…

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New Research Finds That Secretory Gel Protein Inhibits Cancer Immunity

How does the human body fight against tumor formation? The human immune system includes many kinds of immune cells, among which type 1 conventional dendritic cells (cDC1) are essential for effective anti-tumor immunity. It can recognize tumor antigen and induce the anti-tumor immune effect of CD8 + T cells. When cDC1 is absent, CD8 + T cell-driven tumor immunity will subside, and the therapeutic effect of CD8 + T cell…

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In SARS-CoV-2 Infection and Cytokine Shock Syndrome, TNF-α and IFN-γ Cause Inflammatory Cell Death, Tissue Damage and Death

The COVID-19 pandemic continues to cause major illness and death, while treatment options are still limited. In a new study, researchers from the St. Jude Children’s Research Hospital in the United States have discovered a potential strategy to prevent life-threatening inflammation, lung damage, and organ failure in COVID-19 patients. The relevant research results were published in the Cell. The title of the paper is “Synergism of TNF-α and IFN-γ triggers…

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STING Is Involved in the Occurrence of Motor Neurological Diseases

In a recent study, researchers from the University of Melbourne revealed the mechanism of inflammation that slows the onset of motor neuron disease (MND), thereby providing hope for people suffering from this debilitating and incurable disease.   They found that by blocking immune receptor STING, they can significantly prevent inflammation in cells of MND patients, paving the way for the development of new drugs for neurodegenerative diseases such as MND….

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Identify a Key Protein that Can Regulate the Female Body’s Estrogen Cycle – RSK2

Recently, in a research report titled “RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha” published in the Cell Reports, scientists from Vanderbilt University and other institutions found a key regulatory protein through research that can regulate the body’s estrogen cycle.   Oral contraceptives will moderately increase the risk of breast cancer in women, and birth control methods will use estrogen, a hormone that binds to…

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TDP-43 and Paraspeckle: Key Factor to Determine Stem Cells Differentiated or Remain Pluripotent

Induced pluripotent stem cells (iPS cells) can be transformed into any cells in the body or maintain their original form. In a new study, researchers from research institutions such as the Helmholtz Center in Germany described how cells decide which of these two directions to choose. In their research, they identified a protein and a ribonucleic acid (RNA) that played a very important role in this process. Their findings also…

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