As cells age, they experience aging, a state where they stop growing but continue to release inflammatory and tissue-degrading molecules. When a person is young, the immune system will respond by eliminating aging cells, commonly known as “zombie cells”. However, zombie cells will continue to exist and lead to a series of age-related health problems and diseases. In a new study, researchers from the Mayo Clinic in the United…
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In Situ PEG Modification of CAR-T Cells Can Alleviate Cytokine Release Syndrome and Neurotoxicity
In recent years, cancer researchers have cheered the arrival of chimeric antigen receptor (CAR) T-cell therapy, which has achieved encouraging results and changed the treatment methods of various cancers. CAR-T cell therapy targets cancer cells through genetically modified patients’ T cells, thereby achieving a significant cure rate for previously incurable cancers. Currently, six CAR-T cell therapies have been approved by the US Food and Drug Administration (FDA), and several…
Scientists have found 32 proteins related to dementia in the blood of middle-aged people based on 25 years of data!
Genome-wide association studies on Alzheimer’s disease (AD) have shown that its biological process is very complex and not limited to the accumulation of β Amyloid protein (Aβ）and tau protein. Systemic factors and biological processes outside the central nervous system may also affect the risk of dementia and AD. Proteins, as systemic circulating factors, may be driving factors for complex central nervous system diseases, and researchers have been searching for…
By Activating Oct4, Premature Aging Mouse Cells Can Recover Their Vitality
Aging seems to be an irresistible natural law, and at the same time, how to “fight aging and achieve immortality” has become an eternal research topic. Nowadays, thanks to the rapid development of biotechnology, research on anti-aging has become increasingly popular. In 2006, the team of Shinya Yamanaka of Kyoto University in Japan first reported related research on induced pluripotent stem cells (iPSC). They found that by introducing four…
Restoring lost epigenetic information can make aging mammals rejuvenate
An international study lasting for 13 years has shown for the first time that the degradation of the way DNA is assembled and regulated – the so-called epigenetics – can drive the aging of organisms, and has nothing to do with the change of the genetic code itself. This study shows that the destruction of epigenetic information leads to the aging of mice, and the restoration of the integrity of…
CAR-T cell therapy is expected to eliminate residual tumor cells after solid tumor surgery
In a new preclinical study, researchers from the Perelman School of Medicine at the University of Pennsylvania found that as a method of reprogramming patients’ autoimmune cells to attack their blood cancer, CAR-T cell therapy may improve the effectiveness of surgical treatment of solid tumors. The relevant research results were published in the journal Science Advances, and the title of the paper was “Chiric antigen receiver T cells as adjuvant-therapy…
Occluding the ACE2 receptor, renders all mutants incapable of infection!
With successive waves of uncapping, enhancing disease resistance has become one of the most important things at present. Vaccines are the most effective medicines to fight the coronavirus at the moment, and intensified vaccination is also a more desirable method. However, the Omicron virus strain has evolved an extreme ability to infect, and it is not realistic to hope for a vaccine to eliminate the infection. On the other…
Research Reveals Cross-species Transmission of Primate Lentivirus
Humans continue to be threatened by viral diseases such as Ebola, Zika, and Coronavirus. Such emerging/re-emerging virus outbreaks may be caused by cross-species viruses transmitted from wild animals to humans. In order to achieve cross-species transmission, the new host must be exposed to the virus in the old host. Next, the virus acquires certain mutations that may be beneficial for replication in the new host. Finally, by continuing to…
A Special Protein May Help SARS-CoV-2 to Spread Rapidly in Host Cells!
Recently, in a research report published in The FASEB Journal, scientists from Colorado State University and other institutions discovered that a special kind of virus-encoded by SARS-CoV-2 (the virus that induces COVID-19) protein may be directly related to the rapid spread of viruses in the human body. Now scientists have begun to reveal the key features of the SARS-CoV-2 virus through the use of basic research tools and bioinformatics analysis,…
Anti-Inflammatory Drug Anakinra May Improve Respiratory Function in Some Severe COVID-19 Patients
A small study of 8 patients in Greece found that the clinically approved anti-inflammatory drug anakinra (anakinra, which is essentially an IL-1 inhibitor) for the treatment of rheumatoid arthritis It can improve the respiratory function of severe COVID-19 (coronavirus disease 2019, 2019 coronavirus disease) patients. The eight patients also suffered from a disease called secondary hemophagocytic lymphohistiocytosis (sHLH), which was characterized by excessive immune system activation and organ failure. One…