Molecular Mechanism behind MAF Protein Promoting Breast Cancer Metastasis

Breast cancer is the most common type of cancer among women. There are more than 2 million new cases of breast cancer every year. The survival rate of patients is very high, about 90%, when the tumor is still limited to breast tissue; however, when cancer cells spread beyond breast tissue and begin to form metastases in other organs, it significantly worsens the patient’s prognosis and poses great challenges to…

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E-cadherin Found to Be an Essential Protein for Metastasis of Various Breast Cancers

Metastasis is a major cause of death in cancer patients. According to the inverse relationship between migration and E-cadherin levels in vitro, it has been proposed that invasion and metastasis of the surrounding tissues begin after the loss of the intercellular adhesion protein E-cadherin. However, this hypothesis is inconsistent with the observation that the majority of breast cancers are invasive ductal carcinomas and express E-cadherin in the primary tumor and…

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BCR: Targeting Collagen XIII Protein Is Expected to Successfully Treat Breast Cancer Metastasis

Recently, researchers from the University of Kentucky found that targeting a protein called collagen XIII  may effectively inhibit the metastasis of breast cancer. And the article related was published on Breast Cancer Research.   Breast cancer begins in epithelial cells, cells that are arranged in organs and tissues of the body. In general, most of the epithelial cells die when detached from the extracellular matrix. This type of programmed cell…

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Tumor Genetic Testing—Hot Point of This Year!

“Cancer is the most common genetic disease, while all cancers are derived from abnormal DNA sequences.” Professor Michael Stratton, header of the Sanger Institute at the University of Cambridge, pointed out that although different cancers have different incentives and symptoms, but can all be explained by gene mutations. No matter the Human Genome Project (HGP), the Cancer Genome Project (TCGA), the 100,000-person Genome or the “Moon Shots” program of the…

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CXCL12-CXCR4/CXCR7, Two Axes to Repress Breast Cancer

Recently, there are two articles which reported the study on CXCL12 and breast cancer. Let’s take a glance on these new results. Breast cancer (BC) remains the most frequent cancer and the major cause of cancer-associated death in women. Based on histopathological analysis commonly used in clinical practice, BC has been identified as a heterogeneous disease classified into three main subtypes: Luminal (Lum), HER2 and triple-negative (TN), which have been…

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What Makes Cancer So Fatal?

There exists, in some cancers, some abnormal cells similar to stem cells. These cells are as factories that are working overtime. They quickly produce a copy of their own and from time to time generate some variations. What’s worse, those cells can spread to other tissues of the body, and eventually leading to cancer metastasis.   Researchers in Salk institution found that, Sox10 can determine whether cells will transform into…

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