Protein post-translational modifications (PTM) include phosphorylation, methylation, acetylation etc. Protein expression is regulated by genomics and epigenetics, and after expression, it needs to be modified to different degrees to perform the required functions. PTM research is crucial. Here, let’s review the significant research in the field of protein modification in 2018. PNAS: Ubiquitin-like protein ubiquilin 2 (UBQLN2) regulates ALS/FTD-linked FUS-RNA complex kinetics and stress granule formation The ubiquitin-like protein…
protein modification
How Does Protein Accomplish “Dressing Up”?
It’s widely known that numerous of physiological and biochemical processes within cells are accomplished by protein. A tiny cell can contain millions of proteins which are translated and synthesized by ribosome. However, after synthesis, these protein molecules often have to undergo post-translational modification, which has important biological significance. Ubiquitinylation is one type of post-translational modification. In other words, after “dressing up” by some “junior partners”, proteins were sent for “mission”….