The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis

Hainan Medical College’s Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University’s Chen Zhu jointly published a research paper on PNAS titled “The impact of age and number of mutations on the size of clonal hematopoiesis”, which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and…

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JCI: STAT3 Inhibitor May Provide New Hope for Leukemia Treatment

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are malignant hematopoietic stem cell disorders, and abnormal stem cell populations in hematopoietic stem and progenitor cells can cause disease. Traditional treatments to date can not completely eliminate these abnormal hematopoietic stem cells associated with the disease.   Recently, researchers from the Albert Einstein College of Medicine have discovered a prognosis molecule that predicts both MDS and AML. Furthermore, an antisense oligonucleotide…

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Novel Explanation for “Runner’s High”

Running is a pleasant thing. And the happiness, freedom and the feeling of energetic is never just owing to the function of endorphin. A recent study published on Cell Metabolism suggested that dopamine, an important neurotransmitter, has influence on this so-called “runner’s high” too.   The researchers pointed out that this “reward effect” in exercise is under the regulation of leptin, which can inhibit the body’s physical activity through dopamine…

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