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Recombinant Human Snurportin 1, His-tagged

Cat. No.: SNUPN-2746H
Product Overview: Recombinant human Snurportin-1 protien, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =43.3 (380aa) confirmed by MALDI-TOF.
Description: SNUPN, also known as KPNBL or RNUT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It specifically binds the terminal 2,2,7-m3G-cap at the 5" end of U snRNPs and functions to transport U snRNPs into the nucleus via an association with Importin β.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN
Purity: > 90% by SDS – PAGE.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: SNUPN snurportin 1 [ Homo sapiens ]
Synonyms: SNUPN; snurportin 1; KPNBL; RNUT1; Snurportin1; snurportin-1; RNA U transporter 1; RNA, U transporter 1; RNA U transporter 1; SPN1
Gene ID: 10073
mRNA Refseq: NM_001042581
Protein Refseq: NP_001036046
MIM: 607902
UniProt ID: O95149
Chromosome Location: 15q24.2
Function: RNA cap binding; protein transporter activity

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