Recombinant Human PPP3R1, His-tagged
Cat.No. : | PPP3R1-3471H |
Product Overview : | Recombinant human PPP3R1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PPP3R1-3471H |
Description : | PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl. |
Molecular Weight : | 21.5 kDa (190aa), confirmed by MALDI-TOF |
Purity : | > 90 % by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | PPP3R1 protein phosphatase 3, regulatory subunit B, alpha [ Homo sapiens ] |
Synonyms : | protein phosphatase 3, regulatory subunit B, alpha; CNB; CNB1; CALNB1; PPP3R1; calcineurin subunit B type 1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); OTTHUMP00000201960; OTTHUMP00000201961; Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
Gene ID : | 5534 |
mRNA Refseq : | NM_000945 |
Protein Refseq : | NP_000936 |
MIM : | 601302 |
UniProt ID : | P63098 |
Chromosome Location : | 2p15 |
Pathway : | Amyotrophic lateral sclerosis (ALS); Alzheimer"s disease; Long-term potentiation; B cell receptor signaling pathway; T cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; VEGF signaling pathway; Axon guidance; Wnt signaling pathway; Apoptosis; Oocyte meiosis; Calcium signaling pathway; MAPK signaling pathway; Apoptosis; Opioid Signalling |
Function : | calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; protein binding |
Products Types
◆ Recombinant Protein | ||
PPP3R1-7043M | Recombinant Mouse PPP3R1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PPP3R1-4300R | Recombinant Rat PPP3R1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PPP3R1-7366H | Recombinant Human PPP3R1, His tagged | +Inquiry |
PPP3R1-13269M | Recombinant Mouse PPP3R1 Protein | +Inquiry |
PPP3R1-5969H | Recombinant Human PPP3R1 Protein (Gly2-Val170), N-GST tagged | +Inquiry |
◆ Lysates | ||
PPP3R1-001HCL | Recombinant Human PPP3R1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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