"PTP4A2" Related Products


Recombinant Human PTP4A2(2-167), His-tagged

Cat. No.: PTP4A2-505H
Product Overview: Recombinant human PTP4A2 protein(2-167) with N-terminal His tag was expressed in anE.coliexpression system, MW= 19.1 kDa.
Description: Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene. he protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.
Source: E.coli.
Purity: > 90%.
Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
Specific Activity: 0.334 pmol/min/μg, Assay conditions: enzyme was incubated in50mM Tris pH7.4, 150mM NaCl 5mM DTT, and 12.5mM PNPP as a substrate for 2h at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage: >6 months at –80°C.
Gene Name: PTP4A2 protein tyrosine phosphatase type IVA, member 2 [ Homo sapiens ]
Synonyms: PTP4A2; protein tyrosine phosphatase type IVA, member 2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b; Protein tyrosine phosphatase type IVA 2; EC; Protein-tyrosine phosphatase 4a2; BM-008; Protein-tyrosine phosphatase of regenerating liver 2
Gene ID: 8073
mRNA Refseq: NM_080391
Protein Refseq: NP_536316
MIM: 601584
UniProt ID: Q12974
Chromosome Location: 1p35
Function: prenylated protein tyrosine phosphatase activity; hydrolase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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