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Recombinant Mouse Tigit, His tagged

Cat.No. : Tigit-2348M
Product Overview : Recombinant Mouse Tigit (NP_001139797.1) extracellular domain (Met 1-Gly 141), fused with a C-terminal polyhistidine tag, was produced in Human Cell.
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Source : Human Cells
Species : Mouse
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Molecular Mass : The secreted recombinant mouse TIGIT comprises 127 amino acids and has a calculated molecular mass of 14.2 kDa. As a result of glycosylation, the apparent molecular mass of rmSIRPA is approximately 20-25 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus ]
Official Symbol : Tigit
Gene ID : 100043314
mRNA Refseq : NM_001146325
Protein Refseq : NP_001139797

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which types of cancers is TIGIT inhibition being investigated? 12/02/2022

TIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.

How is TIGIT relevant in autoimmune diseases? 05/14/2022

TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.

What clinical applications does TIGIT have in cancer therapy? 06/11/2020

TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.

How does TIGIT differ from other immune checkpoint proteins like PD-1 and CTLA-4? 04/22/2020

TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.

Are there any potential side effects associated with TIGIT-targeted therapies? 01/12/2016

As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.

Customer Reviews (3)

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11/25/2022

    With its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.

    08/05/2017

      Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.

      05/21/2017

        The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.

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