Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 11,His-tagged
Cat.No. : | TNFSF11-349H |
Product Overview : | Recombinant humanTNFSF11 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNFSF11-349H |
Description : | TNFSF11, also knownas RANKL, is a member of the tumor necrosis factor (TNF) cytokine familywhich is a ligand for osteoprotegerin and functions as a key factor forosteoclast differentiation and activation. TNFSF11 also has a function in theimmune system, where it is expressed by T helper cells and is thought to beinvolved in dendritic cell maturation. TNFSF11 is important in bonemetabolism. This natural and necessary surface-bound molecule (also known asCD254) found on osteoblasts serves to activate osteoclasts, which are thecells involved in bone resorption. |
Concentration : | 0.5 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCland 1mM DTT. |
Purity : | > 80% by SDS -PAGE |
Sequence : | 140-317 amino acids:MGSSHHHHHH SSGLVPRGSH MIRAEKAMVD GSWLDLAKRS KLEAQPFAHL TINATDIPSG SHKVSLSSWYHDRGWAKISN MTFSNGKLIV NQDGFYYLYA NICFRHHETS GDLATEYLQL MVYVTKTSIK IPSSHTLMKGGSTKYWSGNS EFHFYSINVG GFFKLRSGEE ISIEVSNPSL LDPDQDATYF GAFKVRDID |
Molecular Mass : | 22.3 kDa(199aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | TNFSF11 |
Gene Name : | TNFSF11tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ] |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11;ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factorligand superfamily member 11; OTTHUMP00000018328; OTTHUMP00000178585;osteoprotegerin ligand; osteoclast differentiation factor; TNF-relatedactivation-induced cytokine; receptor activator of nuclear factor kappa Bligand; receptor activator of nuclear factor kappa-B ligand |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Chromosome Location : | 13q14 |
Pathway : | Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling;Osteoclast differentiation; Rheumatoid arthritis |
Function : | cytokineactivity; receptor activity; tumor necrosis factor receptor binding; tumornecrosis factor receptor superfamily binding |
Products Types
◆ Recombinant Protein | ||
Tnfsf11-9481M | Recombinant Mouse Tnfsf11 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF11-316H | Recombinant Active Human TNFSF11 Protein, His-tagged(C-ter) | +Inquiry |
Tnfsf11-85M | Active Recombinant Mouse Tnfsf11 Protein (Pro143-Asp316), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TNFSF11-2025R | Recombinant Rat TNFSF11 Protein | +Inquiry |
Tnfsf11-2138M | Recombinant Mouse Tnfsf11 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-1586MCL | Recombinant Mouse TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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