Recombinant Human C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)

• Cat.No.: FIGF-625H
• Product Overview: Recombinant human FIGF proteinwas expressed in 293 cells.

Specification

• Cat. No.: FIGF-625H
• Description: FIGF, a member ofthe VEGF/PDGF family of structurally related proteins, is a potent antigeniccytokine. It promotes endothelial cell growth, promotes lymphangiogesis, andcan also affect vascular permeability. FIGF is highly expressed in the lung,heart, small intestine and fetal lung, and at lower levels in the skeletalmuscle, colon, and pancreas. During embryogenesis, FIGF may play a role inthe formation of the venous and lymphatic vascular systems. It alsoparticipates in the growth and maintenance of differentiated lymphatic endotheliumin adults. Both VEGFC and FIGF are over-expressed in certain cancers, and theresulting elevated levels of VEGFC or FIGF tend to correlate with increasedlymphatic metastasis.
• Source: Human
• Host: 293 cells
• Form: Suppliedas a lyophilized powder.
• Purity: > 95% pure by SDSPAGE and HPLC
• Sequence: Region of FIGFprotein corresponding to amino acids: FAATFYDIET LKVIDEEWQR TQCSPRETCVEVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTGCKCLPTAPRH PYSIIRR
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: FIGF

Gene Information

• Gene Name: FIGF c-fos induced growth factor(vascular endothelial growth factor D) [ Homo sapiens ]
• Synonyms: FIGF; c-fos induced growth factor (vascularendothelial growth factor D); VEGFD; VEGF-D; Vascular endothelial growthfactor D; c-Fos-induced growth factor; vascular endothelial growth factor D; OTTHUMP00000022960
• Gene ID: 2277
• mRNA Refseq: NM_004469
• Protein Refseq: NP_004460
• MIM: 300091
• UniProt ID: O43915
• Chromosome Location: Xp22.31
• Pathway: Bladder cancer;Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer;Pathways in cancer; Renal cell carcinoma; mTOR signaling pathway; Hemostasis;Signaling by VEGF
• Function: growth factor activity;platelet-derived growth factor receptor binding; protein homodimerizationactivity; vascular endothelial growth factor receptor 3 binding