Cat. No.: |
PPM1G-1756H |
Product Overview: |
Recombinant humanPPM1G protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography. |
Description: |
PPM1G, as known asprotein phosphatase 1G, is a member of the PP2C family of Ser/Thr proteinphosphatases that are negative regulators of cell stress response pathways.This enzyme localizes to the cytoplasm and is widely expressed, with mostabundant expression detected in testis, skeletal muscle and heart. It isnecessary for the dephosphorylation of pre-mRNA splicing factors, which is animportant process for the formation of the functional spliceosome. |
Concentration: |
1 mg/ml |
Source: |
Human |
Host: |
E.coli |
Form: |
Supplied as a liquidin 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl, 1mM DTTand 0.1mM PMSF. |
Purity: |
> 85% by SDS -PAGE |
Sequence: |
1-546 amino acids:MGSSHHHHHH SSGLVPRGSH MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELDSETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGRPTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEAGPEDS |
Molecular Mass: |
61.4 kDa (566aa) |
Applications: |
SDS-PAGE |
Storage: |
Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol: |
PPM1G |