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Recombinant Mouse Protein Arginine N-methyltransferase 1, His-MBP-tagged

Cat. No.: Prmt1-1762M
Product Overview: Recombinant mousePRMT1, fused to His-MBP tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
Description: Protein arginineN-methyltransferase 1 (PRMT1) is a type I methyltransferase that transfers amethyl group from S-adenosylmethionine to guanidino nitrogens of arginineresidues to form monomethylarginine and asymmetric dimethylarginine.Functions of type I arginine methylation in proteins may include regulationof transcription, modulation of the affinity of nucleic acid-bindingproteins, regulation of interferon signaling pathways, and targeting ofnuclear proteins. Mouse PRMT1 shares 99.9% sequence identity with the humanproteins.
Concentration: 1 mg/ml
Source: Mouse
Host: E. coli
Form: Supplied as a liquidin 40 mM Tris, pH 8.0, containing 100 mM NaCl, 4 mM MgCl2, 2 mM DTT, and 40%glycerol.
Purity: > 90% pure bySDS-PAGE
Sequence: 11-353 amino acids:MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFWAHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEIPALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNKHMNAD
Molecular Mass: 84 kDa (750 aa)
Applications: SDS-PAGE
Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: Prmt1
Gene Name: Prmt1protein arginine N-methyltransferase 1 [ Mus musculus ]
Synonyms: Prmt1; proteinarginine N-methyltransferase 1; Mrmt1; Hrmt1l2; AW214366;6720434D09Rik; OTTMUSP00000022387; OTTMUSP00000022390; OTTMUSP00000022391;OTTMUSP00000022392; arginine N-methyltransferase 1; histone-arginineN-methyltransferase PRMT1; heterogeneous nuclear ribonucleoproteinsmethyltransferase-like 2; EC 2.1.1.125
Gene ID: 15469
mRNA Refseq: NM_019830
Protein Refseq: NP_062804
UniProt ID: Q9JIF0
Chromosome Location: 7 B4; 7 23.1 cM
Pathway: Androgen ReceptorSignaling Pathway; Tryptophan metabolism; mRNA processing
Function: protein binding;methyltransferase activity; histone-arginine N-methyltransferase activity;histone methyltransferase activity (H4-R3 specific); histonemethyltransferase activity; enzyme binding; core promoter proximal region DNAbinding; [cytochrome c]-arginine N-methyltransferase activity;N-methyltransferase activity; protein methyltransferase activity;protein-arginine omega-N asymmetric methyltransferase activity; snoRNPbinding; transferase activity

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