Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged

Cat. No.: NCF1-1721H
Product Overview: Recombinant humanNCF1 protein, fused to His-tag at C-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
Description: Neutrophil cytosolicfactor 1, also known as NCF1, is a cytosolic subunit of neutrophil NADPHoxidase. NCF1, along with NCF2 and a membrane bound cytochrome b558, isrequired for activation of the latent NADPH oxidase necessary for superoxideproduction. Defects in NCF1, often resulting from recombination between NCF1and a nearby homologous pseudogene, cause chronic granulomatous disease.
Concentration: 0.5 mg/ml
Source: Human
Host: E. coli
Form: Supplied as a liquidin 20 mM Tris-HCl buffer, pH 8.0, containing 1 mM DTT, 20% glycerol and 0.1 MNaCl.
Purity: > 90% pure bySDS-PAGE
Sequence: 1-390 amino acids:MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKTLKEMFPI EAGAINPENRIIPHLPAPKW FDGQRAAENR QGTLTEYCST LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYLMPKDGKSTAT DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGWWFCQMKA KRGWIPASFLEPLD
Molecular Mass: 45.7 kDa (398 aa)confirmed by MALDI-TOF
Applications: SDS-PAGE
Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: NCF1
Gene Name: NCF1neutrophil cytosolic factor 1 [ Homo sapiens ]
Synonyms: NCF1; neutrophil cytosolic factor 1;NCF1A; NOXO2; p47phox; FLJ79451; SH3PXD1A; NCF-1; NCF-47K; p47-phox; nox organizer 2; OTTHUMP00000195569; nox-organizing protein 2; NADPH oxidase organizer 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chronic granulomatous disease protein; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
Gene ID: 653361
mRNA Refseq: NM_000265
Protein Refseq: NP_000256
MIM: 608512
UniProt ID: P14598
Chromosome Location: 7q11.23
Pathway: Chemokine signalingpathway; Fc gamma R-mediated phagocytosis; Leishmaniasis; Leukocyte transendothelial migration; Osteoclastdifferentiation; Phagosome; RAC1 signaling pathway
Function: superoxide-generatingNADPH oxidase activity; protein binding; phosphatidylinositol binding;electron carrier activity; SH3 domain binding; GTPase activity; GTP binding

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