Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged

Cat. No.: NCF1-1721H
Product Overview: Recombinant humanNCF1 protein, fused to His-tag at C-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
Description: Neutrophil cytosolicfactor 1, also known as NCF1, is a cytosolic subunit of neutrophil NADPHoxidase. NCF1, along with NCF2 and a membrane bound cytochrome b558, isrequired for activation of the latent NADPH oxidase necessary for superoxideproduction. Defects in NCF1, often resulting from recombination between NCF1and a nearby homologous pseudogene, cause chronic granulomatous disease.
Concentration: 0.5 mg/ml
Source: Human
Host: E. coli
Form: Supplied as a liquidin 20 mM Tris-HCl buffer, pH 8.0, containing 1 mM DTT, 20% glycerol and 0.1 MNaCl.
Purity: > 90% pure bySDS-PAGE
Sequence: 1-390 amino acids:MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKTLKEMFPI EAGAINPENRIIPHLPAPKW FDGQRAAENR QGTLTEYCST LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYLMPKDGKSTAT DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGWWFCQMKA KRGWIPASFLEPLD
Molecular Mass: 45.7 kDa (398 aa)confirmed by MALDI-TOF
Applications: SDS-PAGE
Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: NCF1
Gene Name: NCF1neutrophil cytosolic factor 1 [ Homo sapiens ]
Synonyms: NCF1; neutrophil cytosolic factor 1;NCF1A; NOXO2; p47phox; FLJ79451; SH3PXD1A; NCF-1; NCF-47K; p47-phox; nox organizer 2; OTTHUMP00000195569; nox-organizing protein 2; NADPH oxidase organizer 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chronic granulomatous disease protein; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
Gene ID: 653361
mRNA Refseq: NM_000265
Protein Refseq: NP_000256
MIM: 608512
UniProt ID: P14598
Chromosome Location: 7q11.23
Pathway: Chemokine signalingpathway; Fc gamma R-mediated phagocytosis; Leishmaniasis; Leukocyte transendothelial migration; Osteoclastdifferentiation; Phagosome; RAC1 signaling pathway
Function: superoxide-generatingNADPH oxidase activity; protein binding; phosphatidylinositol binding;electron carrier activity; SH3 domain binding; GTPase activity; GTP binding

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.