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Recombinant Human Interleukin 11

Cat. No.: IL11-551H
Product Overview: Recombinant HumanIL11 is a single, non-glycosylated polypeptide chain containing 178 aminoacids. IL11 is expressed in E. coli, MW 19.1 kDa.
Description: Interleukin 11 (IL11)is a protein that in humans is encoded by the IL11 gene. IL11 is amultifunctional cytokine first isolated in 1990 from bone marrow-derivedstromal cells. It is a key regulator of multiple events in hematopoiesis,most notably the stimulation of megakaryocyte maturation.It is also knownunder the names adipogenesis.
Source: Human
Host: E. coli
Form: Lyophilizedfrom a 0.2μm filtered concentrated solution in PBS, pH 7.4.
Purity: >97% asdetermined by HPLC and SDS-PAGE analyses.
Sequence: PGPPPGPPR VSPDPRAELDSTVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQWLRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGGLHLTLDWAVR GLLLLKTRL
Molecular Weight: 19.1 kDa
Biological Activity: The ED50as determined by the dose-dependant stimulation of the proliferation ofmurineB9-11 was found to be less than 1 ng/ml, corresponding to a specificactivity of 1 x 107 IU/mg.
Endotoxin Level: Less than0.1 ng/µg (1 EU/µg) of recombinant human IL11.
Reconstitution: Centrifugevial prior to opening. Add sterile distilled water or aqueous buffer to a concentrationof 0.1-1.0 mg/mL. Further dilutions should be made in appropriate bufferedsolutions.
Storage: Stableat 2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for upto 1 week at 2-8°C. For longer term, store in working aliquots below -20°C.Avoid repeated freeze/thaw cycles.
OfficialSymbol: IL11
Gene Name: IL11 interleukin 11 [ Homosapiens ]
Synonyms: IL11; interleukin 11; AGIF; IL-11; interleukin-11; Oprelvekin;oprelvekin; adipogenesis inhibitory factor; Adipogenesis inhibitory factor
Gene ID: 3589
mRNA Refseq: NM_000641
Protein Refseq: NP_000632
MIM: 147681
UniProt ID: P20809
Chromosome Location: 19q13.3-q13.4
Pathway: Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway;Rheumatoid arthritis
Function: cytokineactivity; growth factor activity; interleukin-11 receptor binding

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