"Il11" Related Products

Expand
Expand

Recombinant Mouse interleukin 11

Cat. No.: Il11-586M
Product Overview: RecombinantIl11 is a disulfide-linked monomer protein consisting of 179 amino acidresidue subunits, and migrates as an approximately 19 kDa protein undernon-reducing conditions and reducing conditions in SDS-PAGE, and waslyophilized from a 0.2 μm filtered PBS solution.
Description: Il11 issecreted by bone marrow stromal cells (fibroblasts)and is produced also bya number of mesenchymal cells. The Il11receptor (alpha chain) utilizes gp130 as its signal transducer, which isalso a component of other cytokine receptors. The alpha chain of the Il11receptor has been identified independently as Etl2. Il11promotes primary and secondary immune responses in vitro and in vivo andmodulates antigen-specific antibody reactions.
Source: Mouse
Host: E. coli
Purity: >95%, asdetermined by SDS-PAGE and HPLC.
Sequence: MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Molecular Weight: Native MouseIl11, generated by the proteolytic removal of the signal peptide andpropeptide, the molecule has a calculated molecular mass of approximately 19kDa.
Biological Activity: The ED(50) wasdetermined by the dose-dependent stimulation of the proliferation of murineT11 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.
Endotoxin: Endotoxin contentwas assayed using a LAL gel clot method. Endotoxin level was found to be lessthan 0.1 ng/µg(1EU/µg).
Reconstitution: A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage: The lyophilized protein is stable forat least 2 years from date of receipt at -20°C. Upon reconstitution, thiscytokine can be stored in working aliquots at 2°C - 8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss ofactivity. Avoid repeated freeze/thaw cycles.
OfficialSymbol: Il11
Pathways: Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response (BioCarta); Hematopoieticcell lineage; Jak-STAT signaling pathway; Rheumatoid arthritis
Gene Name: Il11 interleukin 11 [ Mus musculus ]
Synonyms: Il11; interleukin11; IL-11; interleukin-11
Gene ID: 16156
mRNA Refseq: NM_008350
Protein Refseq: NP_032376
UniProt ID: P47873
Function: cytokine activity; growthfactor activity; interleukin-11 receptor binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.