Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, M

• Cat.No.: PTPRM-5469H
• Product Overview: Recombinant humanPTPRM is expressed in E. coli; it contains the catalytic domain of PTPRM(residues 839-1100) and has a molecular weight of 30.2 kDa.

Specification

• Cat. No.: PTPRM-5469H
• Description: PTPRM is involved inthe control of cell-cell adhesion and the cadherin-catenin complex. It hasalso been shown to bind and recruit RACK1 to thte plasma membrane. Human PTPRMis a receptor protein tyrosine phosphatase containing 1390 amino acids.
• Source: E. coli
• Species: Human
• Form: 25 mMTris-HCl (pH 8.0), 75 mM NaCl, 0.05% Tween-20, 2 mM EDTA, 1 mM DTT and 50%glycerol. Liquid at -20°C.
• Purity: Greaterthan 95% as determined by Coomassie-stained SDS-PAGE gel.
• Specific Activity: 1265 U/μg.One unit will hydrolyze 1 nmol of p-nitrophenyl phosphate per minute at pH7.4 and 30°C. Assay buffer: 50 mM HEPES (pH 7.4), 2 mM EDTA, 3 mM DTT, 100 mMNaCl and 50 mM pNPP.
• Applications: Removal ofphosphates from target substrates. Useful for the study of enzyme kinetics,regulation and for inhibitors screening.
• Storage: 6 monthsat -20°C.
• Pathways: Adherens junction;Cell adhesion molecules (CAMs); Nectin adhesion pathway

Gene Information

• Gene Name: PTPRM protein tyrosinephosphatase, receptor type, M [ Homo sapiens ]
• Official Symbol: PTPRM
• Synonyms: PTPRM; proteintyrosine phosphatase, receptor type, M; RPTPM; RPTPU;PTPRL1; hR-PTPu; R-PTP-MU; receptor-type tyrosine-protein phosphatase mu; OTTHUMP00000162329;protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; proteintyrosine phosphatase, receptor type, mu polypeptid
• Gene ID: 5797
• mRNA Refseq: NM_001105244
• Protein Refseq: NP_001098714
• MIM: 176888
• UniProt ID: P28827
• Chromosome Location: 18p11.2
• Function: cadherin binding;hydrolase activity; protein binding; protein tyrosine phosphatase activity;receptor activity; transmembrane receptor protein tyrosine phosphataseactivity