||Recombinant HumanVHL beta-domai produced in E. coli is a single, non-glycosylated polypeptidechain containing 174 amino acids and having a MW 19.2 kDa.
||The VonHippel-Lindau tumor suppressor also known as pVHL is a protein that in humansis encoded by the VHL gene. Mutations of the VHL gene are associated with VonHippel-Lindau disease.
||The protein (1 mg/ml)is in a buffer of phosphate-buffered Saline (PBS) and 2 mM EDTA, pH 7.4.
||MGSSHHHHHHSSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPRPVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLVNQTELFVPSL NVDGQPIFAN ITLP
||Store at 2-4°C ifentire vial will be used within 1-2 weeks. Store frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
||Adaptive ImmuneSystem; Antigen processing: Ubiquitination and Proteasome degradation; ClassI MHC mediated antigen processing and presentation; ECV complex; HIF-2-alphatranscription factor network; Hypoxic and oxygen homeostasis regulation ofHIF-1-alpha; Immune System; Pathways in cancer; Renal cell carcinoma;Signaling events mediated by VEGFR1 and VEGFR2; Ubiquitin mediatedproteolysis