"VHL" Related Products

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Recombinant Human Von Hippel-Lindau Tumor Suppressor

Cat. No.: VHL-693H
Product Overview: Recombinant HumanVHL beta-domai produced in E. coli is a single, non-glycosylated polypeptidechain containing 174 amino acids and having a MW 19.2 kDa.
Description: The VonHippel-Lindau tumor suppressor also known as pVHL is a protein that in humansis encoded by the VHL gene. Mutations of the VHL gene are associated with VonHippel-Lindau disease.
Source: E. coli
Species: Human
Form: The protein (1 mg/ml)is in a buffer of phosphate-buffered Saline (PBS) and 2 mM EDTA, pH 7.4.
AminoAcid Sequence: MGSSHHHHHHSSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPRPVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLVNQTELFVPSL NVDGQPIFAN ITLP
Storage: Store at 2-4°C ifentire vial will be used within 1-2 weeks. Store frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
OfficialSymbol: VHL
Pathways: Adaptive ImmuneSystem; Antigen processing: Ubiquitination and Proteasome degradation; ClassI MHC mediated antigen processing and presentation; ECV complex; HIF-2-alphatranscription factor network; Hypoxic and oxygen homeostasis regulation ofHIF-1-alpha; Immune System; Pathways in cancer; Renal cell carcinoma;Signaling events mediated by VEGFR1 and VEGFR2; Ubiquitin mediatedproteolysis
Gene Name: VHL von Hippel-Lindau tumorsuppressor [ Homo sapiens ]
Synonyms: VHL; vonHippel-Lindau tumor suppressor; RCA1; VHL1; HRCA1; von Hippel-Lindaudisease tumor suppressor; pVHL; protein G7; OTTHUMP00000158850; OTTHUMP00000158851;elongin binding protein; Von Hippel-Lindau disease tumor suppressor; Protein G7
Gene ID: 7428
mRNA Refseq: NM_000551
Protein Refseq: NP_000542
MIM: 608537
UniProt ID: P40337
Chromosome Location: 3p25.3
Function: protein binding;transcription factor binding

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