Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
Cat.No. : | SERPINE1-5511H |
Product Overview : | Recombinant HumanPlasminogen Activator Inhibitor type 1 tPA Complex. Human PAI-1 stable mutantis reacted with an excess of human sc-tPA at physiological pH. SERPINE1 wasexpressed in E. coli, which having a molecule weight of 97.0 kDa. |
- Specification
- Gene Information
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Cat. No. : | SERPINE1-5511H |
Description : | SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine proteaseinhibitor (serpin) that functions as the principal inhibitor of tissueplasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (SERPINE1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. In addition,protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, isthe main inhibitor of the plasminogen activators. |
Source : | E. coli |
Species : | Human |
Molecule Weight : | 97.0 kDa |
Form : | Liquid in 0.1 MTris-HCl + 0.15 M NaCl, pH 7.4. |
Concentration : | 1.0 mg/ml |
Storage : | Storein working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | SERPINE1 |
Pathways : | Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway;Senescence and Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway |
Gene Name : | SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ] |
Synonyms : | SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpinE1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine(or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activatorinhibitor type 1), member 1 |
Gene ID : | 5054 |
mRNA Refseq : | NM_000602 |
Protein Refseq : | NP_000593 |
MIM : | 173360 |
UniProt ID : | P05121 |
Chromosome Location : | 7q21.3-q22 |
Function : | peptidase inhibitoractivity; protease binding; protein binding; contributes to receptor binding;serine-type endopeptidase inhibitor activity |
Products Types
◆ Native Protein | ||
SERPINE1-29522TH | Native Human SERPINE1 | +Inquiry |
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
◆ Lysates | ||
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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