Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

• Cat.No.: SERPINE1-5488H
• Product Overview: Recombinant Human SERPINE1is expressed in E. coli.

Specification

• Cat. No.: SERPINE1-5488H
• Description: A single mutationat the P1 position of SERPINE1 alters the target specificity of SERPINE1 fromthe plasminogen activators tPA and uPA to Cathepsin G. This mutant contains aP1 Phenylalanine in place of the wild type Arginine residue resulting in aninhibitor with the specificity of antichymotrypsin.
• Source: E. coli
• Species: Human
• Form: Frozen liquid in0.05 M sodium phosphate+0.1 M NaCl+1 mM EDTA, pH 6.6.
• Molecular Weight: 43 kDa
• Concentration: 2.5 mg/ml
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• Pathways: Adipogenesis; BMAL1:CLOCK/NPAS2Activates Gene Expression; Blood Clotting Cascade; Chagas disease (Americantrypanosomiasis); Circadian Clock; Complement and Coagulation Cascades; Directp53 effectors; Dissolution of Fibrin Clot; E2F transcription factor network; HIF-1-alphatranscription factor network; Hemostasis; Platelet activation; Plateletdegranulation; Selenium Pathway; p53 signaling pathway

Gene Information

• Gene Name: SERPINE1 serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1 [ Homo sapiens ]
• Official Symbol: SERPINE1
• Synonyms: SERPINE1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogenactivator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor;serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1; Endothelialplasminogen activator inhibitor; Serpin E1; OTTHUMP00000211478
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121
• Chromosome Location: 7q21.3-q22
• Function: peptidase inhibitoractivity; protease binding; protein binding; contributes_to receptor binding;serine-type endopeptidase inhibitor activity