Recombinant Human Fas (TNF receptor superfamily, member 6)

• Cat.No.: FAS-5411H
• Product Overview: RecombinantHuman soluble FAS receptor is a 157 amino acid polypeptide corresponding tothe TNFR homologous cysteine rich extracellular domain Fas.

Specification

• Cat. No.: FAS-5411H
• Description: The FAS is a deathreceptor on the surface of cells that leads to programmed cell death(apoptosis). It is one of two apoptosis pathways, the other being themitochondrial pathway. FasR is located on chromosome 10 in humans and 19 inmice. Similar sequences related by evolution are found in most mammals.
• Source: E. coli
• Species: Human
• Form: Lyophilized withoutadditives.
• Molecular Weight: 17.6 kDa
• Endotoxin Level: <0.1 ng/pg of FASreceptor
• Purity: >95% asdetermined by SDS-PAGE and HPLC analyses.
• Biological Activity: Determined by itsability to inhibit the cytotoxicity of Jurkat cells. The EDSO is between10-15 pg/ml in the presence of 2 ng/ml of human Fast.
• Reconstitution: Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
• Storage: Lyophilized proteinis stable for 2 years at -20°C. Reconstituted protein is stable for 1 week at2-4°C or for 3 months in working aliquots with a carrier protein (0.1%HSA orBSA) at -20°C. Please note that the addition of any carrier protein into thisproduct may produce unwanted endotoxin. This depends upon the particularapplication employed. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FAS

Gene Information

• Gene Name: FAS Fas (TNF receptorsuperfamily, member 6) [ Homo sapiens ]
• Synonyms: FAS; Fas (TNFreceptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A;TNFRSF6; tumor necrosis factor receptorsuperfamily member 6; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor;OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000217569;apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen;apoptosis-mediating surface antigen FAS; tumor necrosis factor receptorsuperfamily, member 6
• Gene ID: 355
• mRNA Refseq: NM_000043
• Protein Refseq: NP_000034
• MIM: 134637
• UniProt ID: P25445
• Chromosome Location: 10q24.1
• Pathway: Activationof Pro-Caspase 8; Adipogenesis; African trypanosomiasis; Allograft rejection; Alzheimer"s disease; Apoptosis;Apoptosis Modulation by HSP70; Autoimmune thyroid disease; Caspase-8 is formed from procaspase-8; Chagas disease (American trypanosomiasis); Cytokine-cytokine receptor interaction; Death Receptor Signalling; Direct p53 effectors; FasL/ CD95L signaling; InfluenzaA
• Function: binding;identical protein binding; kinase binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity; tumornecrosis factor-activated receptor activity