Recombinant Human Monocyte Chemoattractant Protein 1
Cat.No. : | CCL2-1188H |
Product Overview : | RecombinantHuman CCL2 producedin E. coli is a single, non-glycosylated, polypeptide chain containing 76 aminoacids. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CCL2-1188H |
Description : | CCL2is a protein that in humans is encoded by the CCL2 gene. CCL2 is a smallcytokine belonging to the CC chemokine family. CCL2 recruits monocytes,memory T cells, and dendritic cells to sites of tissue injury, infection, andinflammation. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilizedfrom a 0.2um filtered concentrated (1.0 mg/ml) solution in 20 mM PB, pH 7.4 +150 mM NaCl. |
Molecular Weight : | 8.6 kDa |
Endotoxin Level : | < 0.1 ng/ug (1EU/ug) of protein. |
Purity : | >97% as determined by HPLC and SDS-PAGE analyses. |
Biological Activity : | Measuredby its ability to chemoattract human monocytes using a concentration range of5 - 20 ng/ml. |
Amino Acid Sequence : | QPDAINAPVTCCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT |
Reconstitution : | Centrifuge vial prior to opening. Addsterile distilled water or aqueous buffer containing 0.1% BSA to aconcentration of 0.1-1.0 mg/ml. Please note that the addition of any carrierprotein into this product may produce unwanted endotoxin. This depends uponthe particular application employed. Further dilutions should be made inappropriate buffered solutions. |
Storage : | Stable at2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for up to1 week at 2-8°C. For longer term, store in working aliquots below -20°C.Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | CCL2 |
Gene Name : | CCL2chemokine (C-C motif) ligand 2 [ Homo sapiens ] |
Synonyms : | CCL2; chemokine(C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF;HSMCR30; MGC9434; small inducible cytokine A2 (monocyte chemotactic protein1, homologous to mouse Sig-je); monocyte chemoattractant protein-1; monocytechemotactic and activating factor; monocyte chemotactic protein 1; homologousto mouse Sig-je; monocyte secretory protein JE; small inducible cytokinesubfamily A (Cys-Cys), member 2; OTTHUMP00000163799; C-C motif chemokine 2; Monocytechemoattractant protein 1; Small-inducible cytokine A2 |
Gene ID : | 6347 |
mRNA Refseq : | NM_002982 |
Protein Refseq : | NP_002973 |
MIM : | 158105 |
UniProt ID : | P13500 |
Chromosome Location : | 17q11.2-q12 |
Pathway : | Chagasdisease (American trypanosomiasis); Chemokine receptors bind chemokines; Chemokinesignaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokinereceptor interaction; Diabetes pathways; GPCR ligand binding; Herpes simplexinfection; IL23-mediated signaling events; Influenza A; Malaria; NOD-likereceptor signaling pathway; PERK regulated gene expression; Peptideligand-binding receptors; Rheumatoid arthritis |
Function : | CCR2 chemokine receptor binding; G-protein couple receptorbinding; chemokine activity; heparin binding; protein kinase activity; receptorbinding; signal transducer activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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