"MAP3K3" Related Products

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged

Cat. No. : MAP3K3-1259H
Product Overview : Recombinanthuman full length MAP3K2 with N-terminal GST tag is expressed in Insect cells.
Description : MAP3K3directly regulates MAPK8 and extracellular signal-regulated protein kinase(ERK) pathways by phosphorylating multiple MAP2Ks.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight : 99.8 kDa
Purity : ≥ 90% as determinedby SDS-PAGE analysis.
Specific Activity : 20 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml.
Concentration : 0.22mg/ml
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : MAP3K3
nullValue_other :
FunctionATP binding; MAPkinase kinase kinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity
PDB rendering basedon 2c60. :

Gene Name : MAP3K3 mitogen-activated proteinkinase kinase kinase 3 [ Homo sapiens ]
Synonyms : MAP3K3; mitogen-activatedprotein kinase kinase kinase 3; MEKK3; MAPKKK3; MAPK/ERKkinase kinase 3; EC; MEK kinase 3; MAP/ERK kinasekinase 3
Gene ID : 4215
mRNA Refseq : NM_002401
Protein Refseq : NP_002392
MIM : 609487
UniProt ID : Q99759
Chromosome Location : 17q23.3
Pathway : Cytokine Signalingin Immune system; EGFR1 Signaling Pathway; ErbB1 downstream signaling; Gapjunction; GnRH signaling pathway; HTLV-I infection; IL1-mediatedsignaling events; Immune System; Interleukin-1signaling;Neurotrophinsignaling pathway; Regulation of p38-alpha and p38-beta; Signalingby Interleukins; Insulin Signaling; TNF receptorsignaling pathway; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kBSignaling Pathway; Trk receptor signaling mediated by the MAPK pathway

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