Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged

• Cat.No.: MAP3K3-1259H
• Product Overview: Recombinanthuman full length MAP3K2 with N-terminal GST tag is expressed in Insect cells.

Specification

• Cat. No.: MAP3K3-1259H
• Description: MAP3K3directly regulates MAPK8 and extracellular signal-regulated protein kinase(ERK) pathways by phosphorylating multiple MAP2Ks.
• Source: Insect cells
• Species: Human
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
• Molecular Weight: 99.8 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis.
• Specific Activity: 20 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml.
• Concentration: 0.22mg/ml
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MAP3K3
• Function: ATP binding; MAPkinase kinase kinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity

Gene Information

• Gene Name: MAP3K3 mitogen-activated proteinkinase kinase kinase 3 [ Homo sapiens ]
• Synonyms: MAP3K3; mitogen-activatedprotein kinase kinase kinase 3; MEKK3; MAPKKK3; MAPK/ERKkinase kinase 3; EC 2.7.11.25; MEK kinase 3; MAP/ERK kinasekinase 3
• Gene ID: 4215
• mRNA Refseq: NM_002401
• Protein Refseq: NP_002392
• MIM: 609487
• UniProt ID: Q99759
• Chromosome Location: 17q23.3
• Pathway: Cytokine Signalingin Immune system; EGFR1 Signaling Pathway; ErbB1 downstream signaling; Gapjunction; GnRH signaling pathway; HTLV-I infection; IL1-mediatedsignaling events; Immune System; Interleukin-1signaling;Neurotrophinsignaling pathway; Regulation of p38-alpha and p38-beta; Signalingby Interleukins; Insulin Signaling; TNF receptorsignaling pathway; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kBSignaling Pathway; Trk receptor signaling mediated by the MAPK pathway