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Recombinant Human Plasminogen Activator, Urokinase

Cat. No.: PLAU-1296H
Product Overview: Recombinant HumanLMW-uPA is produced in insect cell culture as the single-chain LMW form forPLAU and receptor binding studies.
Description: PLAU is involved indegradation of the extracellular matrix and possibly tumor cell migration andproliferation. This protein converts Plasminogen to Plasmin by specificcleavage of an Arg-Val bond in Plasminogen. Plasmin in turn cleaves thisprotein at a Lys-Ile bond to form a two-chain derivative in which a singledisulfide bond connects the amino-terminal A-chain to the catalyticallyactive, carboxy-terminal B-chain. This two-chain derivative is also calledHMW-uPA (high molecular weight uPA). HMW-uPA can be further processed intoLMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chainA (A1) and an amino- terminal fragment. LMW-uPA is proteolytically active butdoes not bind to the uPA receptor.
Source: Insect Cell Culture
Species: Human
Formulation: Frozen liquid in0.05M Sodium Acetate pH 5.0+0.1M NaCI+1mM EDTA.
Molecular Weight: 54.0 kDa
Concentration: 2.5 mg/mL
Volume: 0.04 mL
Storage: Store at -70°C.
OfficialSymbol: PLAU
Gene Name: PLAU plasminogen activator,urokinase [ Homo sapiens ]
Synonyms: PLAU; plasminogenactivator, urokinase; ATF; QPD; UPA; URK; u-PA; BDPLT5; urokinase-type plasminogen activator; OTTHUMP00000019849;OTTHUMP00000019850; OTTHUMP00000019851; U-plasminogen activator; plasminogenactivator, urinary
Gene ID: 5328
mRNA Refseq: NM_002658
Protein Refseq: NP_002649
MIM: 191840
UniProt ID: P00749
Chromosome Location: 10q24
Pathway: ATF-2transcription factor network; Blood Clotting Cascade; Complement andCoagulation Cascades; Complement and coagulation cascades; DNA damageresponse (only ATM dependent); Dissolution of Fibrin Clot; E2F transcriptionfactor network; Endochondral Ossification; FGF signaling pathway; Hemostasis;Osteopontin Signaling; Osteopontin-mediated events; Validated transcriptionaltargets of AP1 family members Fra1 and Fra2; Wnt Signaling Pathway; amb2Integrin signaling
Function: peptidaseactivity; protein binding; serine-type endopeptidase activity

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