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Recombinant Human Phosphoglycerate Mutase 2 (muscle), His-tagged

Cat.No. : PGAM2-1932H
Product Overview : Recombinant humanPGAM2 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography.
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  • Gene Information
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Cat. No. : PGAM2-1932H
Description : PGAM2, also known asphosphoglyceratemutase 2, belongs to the phosphoglycerate mutase family.Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolyticpathway. The PGAM is a dimeric enzyme containing, in different tissues,different proportions of a slow-migrating muscle (MM) isozyme, afast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodesmuscle-specific PGAM subunit. Mutations in this gene cause musclephosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Form : Liquid. 20mMTris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT.
Molecular Weight : 30.9 kDa (273aa)confirmed by MALDI-TOF
Purity : > 95%by SDS-PAGE
Concentration : 1 mg/ml (determinedby Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKMEFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFDIPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSLRGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoidrepeated freezing and thawing cycles.
Pathways : Gluconeogenesis; Glucose metabolism;Glycolysis; Glycolysis (Embden-Meyerhof pathway); Glycolysis / Gluconeogenesis; Glycolysisand Gluconeogenesis; Metabolic pathways; MetRabolism of carbohydrates
Gene Name : PGAM2 phosphoglycerate mutase 2(muscle) [ Homo sapiens ]
Official Symbol : PGAM2
Synonyms : PGAM2;phosphoglycerate mutase 2 (muscle); GSD10; PGAMM; PGAM-M; phosphoglyceratemutase 2; BPG-dependent PGAM 2; phosphoglycerate mutase isozyme M;muscle-specific phosphoglycerate mutase
Gene ID : 5224
mRNA Refseq : NM_000290
Protein Refseq : NP_000281
MIM : 612931
UniProt ID : P15259
Chromosome Location : 7p13-p12
Function : 2,3-bisphosphoglycerate-dependentphosphoglycerate mutase activity ; bisphosphoglycerate 2-phosphataseactivity; bisphosphoglycerate mutase activity; cofactor binding ; hydrolaseactivity ; isomerase activity ; phosphoglycerate mutase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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