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Recombinant Human Phosphoglycerate Mutase 2 (muscle), His-tagged

Cat. No.: PGAM2-1932H
Product Overview: Recombinant humanPGAM2 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography.
Description: PGAM2, also known asphosphoglyceratemutase 2, belongs to the phosphoglycerate mutase family.Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolyticpathway. The PGAM is a dimeric enzyme containing, in different tissues,different proportions of a slow-migrating muscle (MM) isozyme, afast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodesmuscle-specific PGAM subunit. Mutations in this gene cause musclephosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT.
Molecular Weight: 30.9 kDa (273aa)confirmed by MALDI-TOF
Purity: > 95%by SDS-PAGE
Concentration: 1 mg/ml (determinedby Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKMEFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFDIPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSLRGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoidrepeated freezing and thawing cycles.
Pathways: Gluconeogenesis; Glucose metabolism;Glycolysis; Glycolysis (Embden-Meyerhof pathway); Glycolysis / Gluconeogenesis; Glycolysisand Gluconeogenesis; Metabolic pathways; MetRabolism of carbohydrates
Gene Name: PGAM2 phosphoglycerate mutase 2(muscle) [ Homo sapiens ]
Official Symbol: PGAM2
Synonyms: PGAM2;phosphoglycerate mutase 2 (muscle); GSD10; PGAMM; PGAM-M; phosphoglyceratemutase 2; BPG-dependent PGAM 2; phosphoglycerate mutase isozyme M;muscle-specific phosphoglycerate mutase
Gene ID: 5224
mRNA Refseq: NM_000290
Protein Refseq: NP_000281
MIM: 612931
UniProt ID: P15259
Chromosome Location: 7p13-p12
Function: 2,3-bisphosphoglycerate-dependentphosphoglycerate mutase activity ; bisphosphoglycerate 2-phosphataseactivity; bisphosphoglycerate mutase activity; cofactor binding ; hydrolaseactivity ; isomerase activity ; phosphoglycerate mutase activity

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