"GPX3" Related Products

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Recombinant Human Glutathione Peroxidase 3 (plasma), His-tagged

Cat. No.: GPX3-1928H
Product Overview: Recombinant humanGPX3(U73C) protein, fused to His-tag at N-terminus, was expressed in E. coliand purified by using conventional chromatography.
Description: GPX3,also known as glutathione peroxidase 3, belongs to the glutathione peroxidasefamily, which functions in the detoxification of hydrogen peroxide. GPX3protects cells and enzymes from oxidative damage, by catalyzing the reductionof hydrogen peroxide, lipid peroxides and organic hydroperoxide, byglutathione. This protein is one of only a few proteins known in highervertebrates to contain selenocysteine, which occurs at the active site ofglutathione peroxidase and is coded by the nonsense (stop) codon TGA.
Form: Liquid. 20mMTris-HCl buffer (pH7.5) containing 40% glycerol, 0.15M NaCl, 1mM DTT.
Molecular Weight: 25.7 kDa(227aa) confirmed by MALDI-TOF.
Purity: > 85%by SDS-PAGE
Concentration: 0.25 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MQSRGQEKSK MDCHGGISGT IYEYGALTID GEEYIPFKQY AGKYVLFVNVASYCGLTGQY IELNALQEEL APFGLVILGF PCNQFGKQEP GENSEILPTL KYVRPGGGFV PNFQLFEKGDVNGEKEQKFY TFLKNSCPPT SELLGTSDRL FWEPMKVHDI RWNFEKFLVG PDGIPIMRWH HRTTVSNVKMDILSYMRRQA ALGVKRK
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Arachidonic acid metabolism; FolateMetabolism; Glutathione metabolism; Oxidative Stress; Selenium Metabolism andSelenoproteins; Selenium Pathway; glutathione redox reactions I
Gene Name: GPX3 glutathione peroxidase 3(plasma) [ Homo sapiens ]
Official Symbol: GPX3
Synonyms: GPX3; glutathione peroxidase 3 (plasma);GPx-P; GSHPx-3; GSHPx-P; glutathione peroxidase 3; GPx-3; plasma glutathioneperoxidase; extracellular glutathione peroxidase; EC 1.11.1.9
Gene ID: 2878
mRNA Refseq: NM_002084
Protein Refseq: NP_002075
MIM: 138321
UniProt ID: P22352
Chromosome Location: 5q23
Function: glutathione binding; glutathione peroxidaseactivity; oxidoreductase activity; selenium binding; transcription factorbinding

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