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Active Recombinant Human Mucosal Vascular Addressin Cell Adhesion Molecule 1, Fc-tagged

Cat.No. : MADCAM1-5684H
Product Overview : Recombinant Human MADCAM1protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (N-terminus) and Met1-Gln333 (C-terminus).
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Cat. No. : MADCAM1-5684H
Description : MADCAM1 is anapproximately 60 kDa type 1 transmembrane glycoprotein. It is an endothelialcell adhesion molecule that belongs to the immunoglobulin) superfamily ofproteins. Human MADCAM1 is synthesized as a 382 amino acid precursor thatcontains an 18 aa signal sequence, a 299 aa extracellular domain, a 21 aatransmembrane segment, and a 44 aa cytoplasmic tail. Within the ECD there isone potential site for N-linked glycosylation. The ECD comprises two Ig-likedomains of 90 aa and 119 aa, respectively, each possessing invariant cysteineresidues that stabilize the Ig loop.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Val23 & Glu29
Molecular Weight : 59.3 kDa
Activity : Measuredby the ability of the immobilized protein to support the adhesion of HUT78human mature cutaneous T cell lymphoma cells. When 5 x 104cells/well are added to recombinant human MADCAM1/Fc Chimera coated plates(2.5 μg/mL with 100 L/well), approximately 50%-70% will adhere after 1 hourincubation at 37°C in the presence of 1 mM MnCl2.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 85-100kDa, reducing conditions.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 200μg/mL in PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name : MADCAM1 mucosal vascularaddressin cell adhesion molecule 1 [ Homo sapiens ]
Official Symbol : MADCAM1
Synonyms : MADCAM1; mucosalvascular addressin cell adhesion molecule 1; MACAM1; mucosal addressin celladhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesionmolecule-1
Gene ID : 8174
mRNA Refseq : NM_130760
Protein Refseq : NP_570116
MIM : 102670
UniProt ID : Q13477
Chromosome Location : 19p13.3
Pathway : Adaptive ImmuneSystem; Cell adhesion molecules (CAMs); Immune System; Immunoregulatoryinteractions between a Lymphoid and a non-Lymphoid cell; Integrin cellsurface interactions; Intestinal immune network for IgA production;Paxillin-independent events mediated by a4b1 and a4b7; Signal Transduction

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MADCAM1 be targeted for other medical conditions? 01/31/2023

While its primary application is in IBD, researchers are exploring the potential of MADCAM1 in other inflammatory conditions.

How effective is vedolizumab in treating IBD? 10/21/2019

Vedolizumab has shown efficacy in inducing and maintaining remission in patients with moderate to severe IBD.

Are there any side effects associated with vedolizumab? 06/21/2018

Common side effects may include headache, abdominal pain, and respiratory tract infections, but it is generally considered a well-tolerated treatment.

What are the challenges in developing MADCAM1-targeted therapies? 06/01/2017

Challenges include finding the right balance between immune suppression and maintaining immune function and addressing potential side effects.

Can MADCAM1 be used as a biomarker for disease activity in IBD? 08/09/2016

MADCAM1 levels can be measured and used as a biomarker to assess disease activity and response to treatment in IBD patients.

Customer Reviews (3)

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Reviews
04/27/2022

    Reputable manufacturers often provide technical support to researchers using MADCAM1 protein.

    11/08/2018

      Manufacturers can ensure high-quality production of MADCAM1 protein, maintaining its purity and integrity.

      10/14/2016

        This guarantees the reliability and reproducibility of research findings and eliminates potential issues arising from impurities or contamination.

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