Recombinant Mouse Fibroblast Growth Factor 7

Cat. No.: Fgf7-530M
Product Overview: Recombinant Mouse Fgf7protein was expressed in E. coli. Cys32-Thr194.
Description: KGF, also known as Fgf7,is one of 22 known members of the mouse FGF family of secreted proteins that playsa key role in development, morphogenesis, angiogenesis, wound healing, and tumorigenesis.Fgf7 expression is restricted to cells of mesenchymal origin. When secreted, itacts as a paracrine growth factor for nearby epithelial cells. Fgf7 speeds woundhealing by being dramatically upregulated in response to damage to skin or internalstructures that results in high local concentrations of inflammatory mediatorssuch as IL1 and TNFα.
Source: E. coli-derived
Form: Lyophilized from a 0.2μm filtered solution in MOPS, Na2SO4, EDTA and DTT withBSA as a carrier protein.
N-terminalSequence: Cys32
Molecular Weight: 18.7 kDa
Activity: Measuredin a cell proliferation assay using 4MBr5 monkey epithelial cells. Rubin, al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED50 for thiseffect is typically 10-50 ng/mL.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 19 kDa,reducing conditions
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 250 μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Fgf7 fibroblast growth factor 7[ Mus musculus ]
Official Symbol: Fgf7
Synonyms: Fgf7; fibroblastgrowth factor 7; Kgf; keratinocyte growth factor; FGF-7; HBGF-7; heparin-bindinggrowth factor 7; Fibroblast growth factor 7, isoform CRA_a; mCG_2096; RP23-386I21.3-001
Gene ID: 14178
mRNA Refseq: NM_008008
Protein Refseq: NP_032034
UniProt ID: Q544I6
Chromosome Location: 2; 2 F-G
Pathway: Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding and activation;FGFR2 ligand binding and activation; FGFR2b ligand binding and activation; FRS2-mediatedcascade; IRS-mediated signalling; IRS-related events; Insulin receptor signallingcascade; MAPK signaling pathway; Melanoma; PI-3K cascade; Pathways in cancer;Phospholipase C-mediated cascade; Regulation of Actin Cytoskeleton
Function: chemoattractant activity;growth factor activity; heparin binding; protein binding; type 2 fibroblast growthfactor receptor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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