"HAAO" Related Products

Expand

Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase, His-tagged

Cat. No.: HAAO-2403H
Product Overview: Recombinant humanHAAO protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques
Description: HAAO is a monomericcytosolic protein belonging to the family of intramolecular dioxygenasescontaining nonheme ferrous iron. This protein catalyzes the synthesis ofquinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxinwhose toxicity is mediated by its ability to activate glutamateN-methyl-D-aspartate receptors. Increased cerebral levels of QUIN mayparticipate in the pathogenesis of neurologic and inflammatory disorders.HAAO has been suggested to play a role in disorders associated with alteredtissue levels of QUIN
Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Molecular Weight: 35kDa (310aa),confirmed by MALDI-TOF
Purity: > 90% by SDS -PAGE
Concentration: 0.5mg/ml (determinedby BCA assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFYQLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDVLFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQAGTPLSLFGDT YETQVIAYGQ GSSEGLRQNV DVWLWQLEGS SVVTMGGRRL SLAPDDSLLV LAGTSYAWERTQGSVALSVT QDPACKKPLG
Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: HAAO3-hydroxyanthranilate 3,4-dioxygenase [ Homo sapiens ]
Official Symbol: HAAO
Synonyms: HAAO; 3-hydroxyanthranilate3,4-dioxygenase; 3 HAO; 3 hydroxyanthranilate 3 4 dioxygenase; 3hydroxyanthranilate dioxygenase; 3 hydroxyanthranilate oxygenase; 3hydroxyanthranilic acid dioxygenase; 3-HAO; 3-hydroxyanthranilate 3;3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase;3HAO_HUMAN; 4-dioxygenase; haao; HAD; HAO; HAD; 3-hydroxyanthranilateoxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO
Gene ID: 23498
mRNA Refseq: NM_012205
Protein Refseq: NP_036337
MIM: 604521
Uniprot ID: P46952
Chromosome Location: 2p
Pathway: Metabolic pathways,organism-specific biosystem; Metabolism, organism-specific biosystem;Metabolism of amino acids and derivatives, organism-specific biosystem; NADbiosynthesis II (from tryptophan), conserved biosystem; Tryptophancatabolism, organism-specific biosystem
Function: 3-hydroxyanthranilate3,4-dioxygenase activity; 3-hydroxyanthranilate 3,4-dioxygenase activity;electron carrier activity; ferrous iron binding; metal ion binding

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.