Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase, His-tagged
Cat.No. : | HAAO-2403H |
Product Overview : | Recombinant humanHAAO protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques |
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Cat. No. : | HAAO-2403H |
Description : | HAAO is a monomericcytosolic protein belonging to the family of intramolecular dioxygenasescontaining nonheme ferrous iron. This protein catalyzes the synthesis ofquinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxinwhose toxicity is mediated by its ability to activate glutamateN-methyl-D-aspartate receptors. Increased cerebral levels of QUIN mayparticipate in the pathogenesis of neurologic and inflammatory disorders.HAAO has been suggested to play a role in disorders associated with alteredtissue levels of QUIN |
Form : | Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
Molecular Weight : | 35kDa (310aa),confirmed by MALDI-TOF |
Purity : | > 90% by SDS -PAGE |
Concentration : | 0.5mg/ml (determinedby BCA assay) |
Sequences of aminoacids : | MGSSHHHHHHSSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFYQLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDVLFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQAGTPLSLFGDT YETQVIAYGQ GSSEGLRQNV DVWLWQLEGS SVVTMGGRRL SLAPDDSLLV LAGTSYAWERTQGSVALSVT QDPACKKPLG |
Storage : | Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | HAAO3-hydroxyanthranilate 3,4-dioxygenase [ Homo sapiens ] |
Official Symbol : | HAAO |
Synonyms : | HAAO; 3-hydroxyanthranilate3,4-dioxygenase; 3 HAO; 3 hydroxyanthranilate 3 4 dioxygenase; 3hydroxyanthranilate dioxygenase; 3 hydroxyanthranilate oxygenase; 3hydroxyanthranilic acid dioxygenase; 3-HAO; 3-hydroxyanthranilate 3;3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase;3HAO_HUMAN; 4-dioxygenase; haao; HAD; HAO; HAD; 3-hydroxyanthranilateoxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO |
Gene ID : | 23498 |
mRNA Refseq : | NM_012205 |
Protein Refseq : | NP_036337 |
MIM : | 604521 |
Uniprot ID : | P46952 |
Chromosome Location : | 2p |
Pathway : | Metabolic pathways,organism-specific biosystem; Metabolism, organism-specific biosystem;Metabolism of amino acids and derivatives, organism-specific biosystem; NADbiosynthesis II (from tryptophan), conserved biosystem; Tryptophancatabolism, organism-specific biosystem |
Function : | 3-hydroxyanthranilate3,4-dioxygenase activity; 3-hydroxyanthranilate 3,4-dioxygenase activity;electron carrier activity; ferrous iron binding; metal ion binding |
Products Types
◆ Recombinant Protein | ||
Haao-346M | Recombinant Mouse Haao Protein, MYC/DDK-tagged | +Inquiry |
HAAO-2432R | Recombinant Rat HAAO Protein, His (Fc)-Avi-tagged | +Inquiry |
HAAO-4547H | Recombinant Human HAAO Protein, GST-tagged | +Inquiry |
HAAO-1038H | Recombinant Human HAAO Protein, His (Fc)-Avi-tagged | +Inquiry |
HAAO-1128R | Recombinant Rat HAAO protein(Met1-Gly286), His-tagged | +Inquiry |
◆ Lysates | ||
HAAO-5650HCL | Recombinant Human HAAO 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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