"TCEA1" Related Products

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Recombinant Human Transcription Elongation Factor A (SII), 1, His-tagged

Cat. No.: TCEA1-6769H
Product Overview: Recombinant humanTCEA1 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.
Description: TCEA1 (Transcriptionelongation factor A protein 1) belongs to the TFS-II family. TCEA1 binds toPol II and functions to cleave the nascent transcript, thereby unlocking thecomplex and allowing transcription to continue. Localized to the nucleus,TCEA1 contains three independently-folding domains, all of which arenecessary for proper binding to Pol II. The arresting sites in DNA have theproperty of trapping a certain fraction of elongating RNA polymerases thatpass through, resulting in locked ternary complexes. Cleavage of the nascenttranscript by S-II allows the resumption of elongation from the new3"-terminus.
Form: Liquid. In 20 mMTris-HCl buffer, pH7.5, 20% glycerol, 1mM DTT, 50mM NaCl
Molecular Weight: 36.5kDa (325aa),confirmed by MALDI-TOF
Purity: > 90% by SDS -PAGE
Concentration: 1mg/ml (determinedby Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMEDEVV RFAKKMDKMV QKKNAAGALD LLKELKNIPM TLELLQSTRI GMSVNAIRKQSTDEEVTSLA KSLIKSWKKL LDGPSTEKDL DEKKKEPAIT SQNSPEAREE STSSGNVSNR KDETNARDTYVSSFPRAPST SDSVRLKCRE MLAAALRTGD DYIAIGADEE ELGSQIEEAI YQEIRNTDMK YKNRVRSRISNLKDAKNPNL RKNVLCGNIP PDLFARMTAE EMASDELKEM RKNLTKEAIR EHQMAKTGGT QTDLFTCGKCKKKNCTYTQV QTRSADEPMT TFVVCNECGN RWKFC
Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: TCEA1transcription elongation factor A (SII), 1 [ Homo sapiens ]
Official Symbol: TCEA1
Synonyms: TCEA1; transcription elongationfactor A (SII), 1; GTF2S, TCEA; transcription elongation factor A protein 1;SII; TF2S; TFIIS
Gene ID: 6917
mRNA Refseq: NM_006756
Protein Refseq: NP_006747
MIM: 601425
Uniprot ID: P23193
Chromosome Location: 8q11.2
Pathway: DNA Repair, organism-specificbiosystem; Dual incision reaction in TC-NER, organism-specific biosystem;Formation and Maturation of mRNA Transcript, organism-specific biosystem;Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specificbiosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat,organism-specific biosystem
Function: DNA binding; metal ion binding;translation elongation factor activity; zinc ion binding

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