"PTGR2" Related Products

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Recombinant Human Prostaglandin Reductase 2, His-tagged

Cat. No.: PTGR2-1957H
Product Overview: Recombinanthuman PTGR2 protein, fused to His-tag at N-terminus, was expressed in E. coliand purified by using conventional chromatography techniques.
Description: PTGR2 belongs to themedium-chain dehydrogenase/reductase superfamily. PTGR2 catalyzes anNADPH-dependent reduction of the conjugated alpha,beta-unsaturated doublebond of 15-keto-PGE(2), a key step in terminal inactivation of prostaglandinsand suppression of PPARgamma-mediated adipocyte differentiation. Selectiveinhibition of PTGR2 may contribute to the improvement of insulin sensitivitywith fewer side effects.
Form: Liquid. In 20 mMTris-HCl buffer, pH 8.0, 10% glycerol, 1mM DTT, 50mM NaCl.
Molecular Weight: 41.1 kDa (375aa),confirmed by MALDI-TOF
Purity: > 90% by SDS-PAGE
Concentration: 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMIVQRV VLNSRPGKNG NPVAENFRME EVYLPDNINE GQVQVRTLYLSVDPYMRCRM NEDTGTDYIT PWQLSQVVDG GGIGIIEESK HTNLTKGDFV TSFYWPWQTK VILDGNSLEKVDPQLVDGHL SYFLGAIGMP GLTSLIGIQE KGHITAGSNK TMVVSGAAGA CGSVAGQIGH FLGCSRVVGICGTHEKCILL TSELGFDAAI NYKKDNVAEQ LRESCPAGVD VYFDNVGGNI SDTVISQMNE NSHIILCGQISQYNKDVPYP PPLSPAIEAI QKERNITRER FLVLNYKDKF EPGILQLSQW FKEGKLKIKE TVINGLENMGAAFQSMMTGG NIGKQIVCIS EEISL
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol: PTGR2
nullValue_other:
Function15-oxoprostaglandin 13-oxidase activity;nucleotide binding; oxidoreductase activity; NOT zinc ion binding
Gene Name: PTGR2prostaglandin reductase 2 [ Homo sapiens ]
Synonyms: PTGR2; prostaglandinreductase 2; OTTHUMP00000245588; OTTHUMP00000245589; OTTHUMP00000245590; OTTHUMP00000245591;OTTHUMP00000245592; OTTHUMP00000245593; OTTHUMP00000245594; PGR2;ZADH1; PRG-2; 15-oxoprostaglandin 13-reductase;15-oxoprostaglandin-delta13-reductase; zinc binding alcohol dehydrogenase,domain containing 1; zinc-binding alcohol dehydrogenase domain-containingprotein 1; EC 1.3.1.48; FLJ39091; zinc binding alcohol dehydrogenase domaincontaining 1; FLJ99229; DKFZp686P10120
Gene ID: 145482
mRNA Refseq: NM_152444
Protein Refseq: NP_689657
MIM: 608642
UniProt ID: Q8N8N7
Chromosome Location: 14q24.3

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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