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Human Myelin basic protein

Cat.No. : MBP-6947H
Product Overview : Human Myelinbasic protein, was highly Purified from human brain by method of Määttä etal.
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Cat. No. : MBP-6947H
Description : MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components.
Source : humanbrain
Concentration : 1mg/mlafter reconstitution
Appearance : White tooff-white powder.
Formulation : Lyophilized. Essentially salt-free.
Purity : >95%(SDS-PAGE; Immunoblot)
Reconstitution : Reconstitutewith distilled water
Application : Can be used toinduce relapsing experimental autoimmune encephalomyelitis in animals. Thisproduct may also be used as a substrate for protein kinases.
Storage : Stable for at least1 year when stored at +4°C. Reconstituted protein is stable for at least sixmonths at -20°C and for at least 24 hours at +37°C in aqueous solution.
Gene Name : MBP myelin basicprotein [ Homo sapiens ]
Synonyms : myelinbasic protein; MGC99675; MBP; Golli-MBP; myelin A1 protein; myelin membraneencephalitogenic protein;OTTHUMP00000163776; OTTHUMP00000174387;OTTHUMP00000174388
Gene ID : 4155
mRNA Refseq : NM_001025081
Protein Refseq : NP_001020252
MIM : 159430
UniProt ID : P02686
Chromosome Location : 18q23
Function : structuralconstituent of myelin sheath

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the MBP gene and its encoded protein? 09/30/2022

The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

How is MBP expression regulated during neural development? 01/11/2021

MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

What role does MBP play in multiple sclerosis (MS)? 09/29/2020

In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

What are the implications of MBP in demyelinating diseases beyond MS? 09/20/2019

Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases? 04/30/2019

Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

Are there any known diseases or conditions associated with mutations or dysregulation of MBP? 03/12/2019

Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

How does MBP contribute to the structure and function of myelin sheaths in the nervous system? 07/14/2018

MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.

Customer Reviews (3)

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Reviews
12/21/2019

    Product exactly as described.

    07/27/2018

      Worked well in ELISA.

      05/13/2018

        Excellent customer support, helpful.

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