Human Myelin basic protein
Cat.No. : | MBP-6947H |
Product Overview : | Human Myelinbasic protein, was highly Purified from human brain by method of Määttä etal. |
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- Gene Information
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Cat. No. : | MBP-6947H |
Description : | MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components. |
Source : | humanbrain |
Concentration : | 1mg/mlafter reconstitution |
Appearance : | White tooff-white powder. |
Formulation : | Lyophilized. Essentially salt-free. |
Purity : | >95%(SDS-PAGE; Immunoblot) |
Reconstitution : | Reconstitutewith distilled water |
Application : | Can be used toinduce relapsing experimental autoimmune encephalomyelitis in animals. Thisproduct may also be used as a substrate for protein kinases. |
Storage : | Stable for at least1 year when stored at +4°C. Reconstituted protein is stable for at least sixmonths at -20°C and for at least 24 hours at +37°C in aqueous solution. |
Gene Name : | MBP myelin basicprotein [ Homo sapiens ] |
Synonyms : | myelinbasic protein; MGC99675; MBP; Golli-MBP; myelin A1 protein; myelin membraneencephalitogenic protein;OTTHUMP00000163776; OTTHUMP00000174387;OTTHUMP00000174388 |
Gene ID : | 4155 |
mRNA Refseq : | NM_001025081 |
Protein Refseq : | NP_001020252 |
MIM : | 159430 |
UniProt ID : | P02686 |
Chromosome Location : | 18q23 |
Function : | structuralconstituent of myelin sheath |
Products Types
◆ Recombinant Protein | ||
MBP-2527H | Recombinant Human MBP protein(101-190 aa), C-His-tagged | +Inquiry |
MBP-1099H | Recombinant Human MBP Protein, His&SUMO-tagged | +Inquiry |
MBP-2755P | Recombinant Pan-species (General) MBP Protein, His/MBP-tagged | +Inquiry |
Mbp-3985M | Recombinant Mouse Mbp Protein, Myc/DDK-tagged | +Inquiry |
MBP-1100H | Recombinant Human MBP Protein, His&SUMO-tagged | +Inquiry |
◆ Native Protein | ||
MBP-89S | Native Swine MBP Protein | +Inquiry |
MBP-6949M | Native Mouse Myelin basic protein | +Inquiry |
MBP-99S | Native Swine MBP | +Inquiry |
◆ Lysates | ||
MBP-4437HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4438HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4436HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Reviews
Q&As (7)
Ask a questionThe MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.
MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.
In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.
Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.
Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.
Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.
MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.
Customer Reviews (3)
Write a reviewProduct exactly as described.
Worked well in ELISA.
Excellent customer support, helpful.
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