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Recombinant Human Uroporphyrinogen III Synthase, His-tagged

Cat.No. : UROS-996H
Product Overview : Recombinant human UROS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography (1-265aa).
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Cat. No. : UROS-996H
Description : UROS, also known as Uroporphyrinogen III synthase, is an enzyme involved in the fourth step of porphyrin metabolism, involved in the conversion of hydroxymethylbilane into uroporphyrinogen III. Defects in this protein can cause molecular lesions that lead to the autosomal recessive Gunther disease, also known as congenital erythropoietic porphyria (CEP).
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl
Molecular Weight : 30.7 kDa(285aa) confirmed by MALDI-TOF
Purity : >95% by SDS - PAGE
Concentration : 1.0 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI FTSPRAVEAAELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGIAMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQALATGIRKALQ PHGCC
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name : UROS uroporphyrinogen III synthase [ Homo sapiens ]
Synonyms : UROS; uroporphyrinogen-III synthase; UROIIIS;hydroxymethylbilanehydrolyase;uroporphyrinogen-III cosynthase; NP_000366.1; EC 4.2.1.75; OTTHUMP00000020710; OTTHUMP00000020712
Gene ID : 7390
mRNA Refseq : NM_000375
Protein Refseq : NP_000366
MIM : 606938
UniProt ID : P10746
Chromosome Location : 10q25.2-q26.3
Function : cofactor binding; lyase activity; uroporphyrinogen-III synthase activity; uroporphyrinogen-III synthase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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