Recombinant Human WW Domain Containing Oxidoreductase, His-tagged

• Cat.No.: WWOX-6922H
• Product Overview: Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 28.3 kDa.

Specification

• Description: WWOX is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Molecular Mass: 28.3 kDa (254aa), confirmed by MALDI-TOF.
• Protein length: 1-234aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: WWOX WW domain containing oxidoreductase [ Homo sapiens ]
• Official Symbol: WWOX
• Synonyms: WWOX; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; FOR; SDR41C1; short chain dehydrogenase/reductase family 41C; member 1; WOX1; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/reductase family 41C, member 1; FRA16D; HHCMA56; PRO0128; D16S432E
• Gene ID: 51741
• mRNA Refseq: NM_016373
• Protein Refseq: NP_057457
• MIM: 605131
• UniProt ID: Q9NZC7
• Chromosome Location: 16q23.3-q24.1
• Pathway: ErbB4 signaling events, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by ERBB4, organism-specific biosystem
• Function: coenzyme binding; cofactor binding; enzyme binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity; protein binding; protein dimerization activity