Recombinant Human Ornithine Decarboxylase 1, His-tagged
Cat.No. : | ODC1-2497H |
Product Overview : | Recombinant human ODC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 53.5 kDa. |
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- Gene Information
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Description : | ODC1 is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. ODC1 plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. Overexpression of the ODC1 gene plays important roles in cell proliferation and the development of cancer. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl. |
Molecular Mass : | 53.5 kDa (484aa) |
Protein length : | 1-461aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMNNFGNE EFDCHFLDEG FTAKDILDQK INEVSSSDDK DAFYVADLGD ILKKHLRWLK ALPRVTPFYA VKCNDSKAIV KTLAATGTGF DCASKTEIQL VQSLGVPPER IIYANPCKQV SQIKYAANNG VQMMTFDSEV ELMKVARAHP KAKLVLRIAT DDSKAVCRLS VKFGATLRTS RLLLERAKEL NIDVVGVSFH VGSGCTDPET FVQAISDARC VFDMGAEVGF SMYLLDIGGG FPGSEDVKLK FEEITGVINP ALDKYFPSDS GVRIIAEPGR YYVASAFTLA VNIIAKKIVL KEQTGSDDED ESSEQTFMYY VNDGVYGSFN CILYDHAHVK PLLQKRPKPD EKYYSSSIWG PTCDGLDRIV ERCDLPEMHV GDWMLFENMG AYTVAAASTF NGFQRPTIYY VMSGPAWQLM QQFQNPDFPP EVEEQDASTL PVSCAWESGM KRHRAACASA SINV |
Purity : | >95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name : | ODC1 ornithine decarboxylase 1 [ Homo sapiens ] |
Official Symbol : | ODC1 |
Synonyms : | ODC1; ornithine decarboxylase 1; ornithine decarboxylase; ODC; |
Gene ID : | 4953 |
mRNA Refseq : | NM_002539 |
Protein Refseq : | NP_002530 |
MIM : | 165640 |
UniProt ID : | P11926 |
Chromosome Location : | 2p25 |
Pathway : | Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; |
Function : | lyase activity; ornithine decarboxylase activity; |
Products Types
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ODC1-1573H | Recombinant Human ODC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Odc1-1883R | Recombinant Rat Odc1 Protein, His-tagged | +Inquiry |
ODC1-2524H | Recombinant Human ODC1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ODC1-3600HCL | Recombinant Human ODC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionAltered ODC1 activity is linked to cancer progression, as polyamines are vital for rapid cell division.
Targeting ODC1 offers potential for cancer therapy by controlling polyamine levels in rapidly dividing cells.
ODC1 is involved in tissue repair processes, aiding in cell regeneration and healing.
ODC1 works with other metabolic enzymes, coordinating the synthesis and regulation of polyamines.
ODC1, ornithine decarboxylase, is crucial for initiating polyamine synthesis, essential for cellular growth and function.
It plays a key role in cell proliferation by providing polyamines necessary for DNA and protein synthesis.
Genetic variations in ODC1 can lead to differences in polyamine synthesis, affecting cell growth and metabolism.
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