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Recombinant Human Ornithine Decarboxylase 1, His-tagged

Cat.No. : ODC1-2497H
Product Overview : Recombinant human ODC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 53.5 kDa.
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Description : ODC1 is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. ODC1 plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. Overexpression of the ODC1 gene plays important roles in cell proliferation and the development of cancer.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
Molecular Mass : 53.5 kDa (484aa)
Protein length : 1-461aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMNNFGNE EFDCHFLDEG FTAKDILDQK INEVSSSDDK DAFYVADLGD ILKKHLRWLK ALPRVTPFYA VKCNDSKAIV KTLAATGTGF DCASKTEIQL VQSLGVPPER IIYANPCKQV SQIKYAANNG VQMMTFDSEV ELMKVARAHP KAKLVLRIAT DDSKAVCRLS VKFGATLRTS RLLLERAKEL NIDVVGVSFH VGSGCTDPET FVQAISDARC VFDMGAEVGF SMYLLDIGGG FPGSEDVKLK FEEITGVINP ALDKYFPSDS GVRIIAEPGR YYVASAFTLA VNIIAKKIVL KEQTGSDDED ESSEQTFMYY VNDGVYGSFN CILYDHAHVK PLLQKRPKPD EKYYSSSIWG PTCDGLDRIV ERCDLPEMHV GDWMLFENMG AYTVAAASTF NGFQRPTIYY VMSGPAWQLM QQFQNPDFPP EVEEQDASTL PVSCAWESGM KRHRAACASA SINV
Purity : >95% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : ODC1 ornithine decarboxylase 1 [ Homo sapiens ]
Official Symbol : ODC1
Synonyms : ODC1; ornithine decarboxylase 1; ornithine decarboxylase; ODC;
Gene ID : 4953
mRNA Refseq : NM_002539
Protein Refseq : NP_002530
MIM : 165640
UniProt ID : P11926
Chromosome Location : 2p25
Pathway : Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem;
Function : lyase activity; ornithine decarboxylase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of altered ODC1 activity on cancer development? 02/28/2021

Altered ODC1 activity is linked to cancer progression, as polyamines are vital for rapid cell division.

What potential therapeutic applications arise from targeting ODC1 in cancer treatment? 10/22/2020

Targeting ODC1 offers potential for cancer therapy by controlling polyamine levels in rapidly dividing cells.

What role does ODC1 play in tissue repair? 10/27/2018

ODC1 is involved in tissue repair processes, aiding in cell regeneration and healing.

How does ODC1 interact with other enzymes in polyamine metabolism? 08/26/2018

ODC1 works with other metabolic enzymes, coordinating the synthesis and regulation of polyamines.

What is the primary role of ODC1 in polyamine synthesis? 12/29/2017

ODC1, ornithine decarboxylase, is crucial for initiating polyamine synthesis, essential for cellular growth and function.

How does ODC1 contribute to cell growth and proliferation? 08/01/2017

It plays a key role in cell proliferation by providing polyamines necessary for DNA and protein synthesis.

How do genetic variations in ODC1 affect cellular metabolism? 07/17/2017

Genetic variations in ODC1 can lead to differences in polyamine synthesis, affecting cell growth and metabolism.

Customer Reviews (3)

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Reviews
10/27/2018

    Enhances research credibility, a dependable research ally.

    12/29/2017

      Critical for decision-making, a vital research resource.

      08/01/2017

        Efficiency and precision, accelerates research timelines.

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