Recombinant Human Heart And Neural Crest Derivatives Expressed 1, His-tagged

• Cat.No.: HAND1-7171H
• Product Overview: Recombinant human HAND1 protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 26 kDa.

Specification

• Description: HAND1 belongs to the basic helix-loop-helix family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol.
• Molecular Mass: 26 kDa (238aa)
• Protein length: 1-215aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA AATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWPQQ VWALELNQ
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: HAND1 heart and neural crest derivatives expressed 1 [ Homo sapiens ]
• Official Symbol: HAND1
• Synonyms: HAND1; heart and neural crest derivatives expressed 1; heart- and neural crest derivatives-expressed protein 1; bHLHa27; eHand; Hxt; Thing1; class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
• Gene ID: 9421
• mRNA Refseq: NM_004821
• Protein Refseq: NP_004812
• MIM: 602406
• UniProt ID: O96004
• Chromosome Location: 5q33
• Pathway: Heart Development, organism-specific biosystem
• Function: bHLH transcription factor binding; enzyme binding; identical protein binding; contributes_to protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; contributes_to transcription regulatory region DNA binding