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Recombinant Human MYD88, His-tagged

Cat.No.: MYD88-7112H
Product Overview: Recombinant human MYD88 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: Myeloid differentiation primary response gene 88, also known as MYD88, acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Molecular Mass: 38.7kDa (345aa)
Protein length: 1-309aa
AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRPD RAEAPGPPAM AAGGPGAGSA APVSSTSSLP LAALNMRVRR RLSLFLNVRT QVAADWTALA EEMDFEYLEI RQLETQADPT GRLLDAWQGR PGASVGRLLE LLTKLGRDDV LLELGPSIEE DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml
Gene Name: MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ]
Official Symbol: MYD88
Synonyms: MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D;
Gene ID: 4615
mRNA Refseq: NM_001172566
Protein Refseq: NP_001166037
MIM: 602170
UniProt ID: Q99836
Chromosome Location: 3p22
Pathway: Activated TLR4 signalling, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function: TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding;

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