"LYN" Related Products

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Recombinant Human LYN, His-tagged

Cat.No.: LYN-7218H
product overview: Recombinant human LYN protein, fused to His-tag at N-terminus, was expressed in E.coli.
description: Tyrosine-protein kinase Lyn, also known as LYN, is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. This protein is Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. It Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN ->MEKK1 ->MKK7 ->SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
source: E. coli
species: Human
tag: His
form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
molecular mass: 61.0 kDa (535aa)
protein length: 1-512aa
aa sequence: MGSSHHHHHH SSGLVPRGSH MGSMGCIKSK GKDSLSDDGV DLKTQPVRNT ERTIYVRDPT SNKQQRPVPE SQLLPGQRFQ TKDPEEQGDI VVALYPYDGI HPDDLSFKKG EKMKVLEEHG EWWKAKSLLT KKEGFIPSNY VAKLNTLETE EWFFKDITRK DAERQLLAPG NSAGAFLIRE SETLKGSFSL SVRDFDPVHG DVIKHYKIRS LDNGGYYISP RITFPCISDM IKHYQKQADG LCRRLEKACI SPKPQKPWDK DAWEIPRESI KLVKRLGAGQ FGEVWMGYYN NSTKVAVKTL KPGTMSVQAF LEEANLMKTL QHDKLVRLYA VVTREEPIYI ITEYMAKGSL LDFLKSDEGG KVLLPKLIDF SAQIAEGMAY IERKNYIHRD LRAANVLVSE SLMCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GCFTIKSDVW SFGILLYEIV TYGKIPYPGR TNADVMTALS QGYRMPRVEN CPDELYDIMK MCWKEKAEER PTFDYLQSVL DDFYTATEGQ YQQQP
purity: >90% by SDS - PAGE
applications: SDS-PAGE
storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
concentration: 1 mg/ml
gene name: LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ]
official symbol: LYN
synonyms: LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; tyrosine-protein kinase Lyn; JTK8; lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; FLJ26625;
Gene ID: 4067
mrna refseq: NM_001111097
protein refseq: NP_001104567
mim: 165120
uniprot id: P07948
chromosome location: 8q13
pathway: Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem;
function: ATP binding; SH3 domain binding; enzyme binding; glycosphingolipid binding; integrin binding; ion channel binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphoprotein binding; platelet-derived growth factor receptor binding; protein binding; protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ubiquitin protein ligase binding;

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