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Recombinant Human KRT19 Protein, His tagged

Cat.No. : KRT19-7239H
Product Overview : Recombinant Human KRT19 Protein with His tag was expressed in E. coli.
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Description : The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
Source : E. coli
Species : Human
Tag : N-His
Molecular Mass : The protein has a calculated MW of 47 kDa.
AA Sequence : MGSSHHHHHHSSGLVPRGSHMGSMT SYSYRQSSATSSFGGLGGGSVRFGP GVAFRAPSIHGGSGGRGVSVSSARF VSSSSSGAYGGGYGGVLTASDGLLA GNEKLTMQNLNDRLASYLDKVRALE AANGELEVKIRDWYQKQGPGPSRDY SHYYTTIQDLRDKILGATIENSRIV LQIDNARLAADDFRTKFETEQALRM SVEADINGLRRVLDELTLARTDLEM QIEGLKEELAYLKKNHEEEISTLRG QVGGQVSVEVDSAPGTDLAKILSDM RSQYEVMAEQNRKDAEAWFTSRTEE LNREVAGHTEQLQMSRSEVTDLRRT LQGLEIELQSQLSMKAALEDTLAET EARFGAQLAHIQALISGIEAQLGDV RADSERQNQEYQRLMDIKSRLEQEI ATYRSLLEGQEDHYNNLSASKVL
Endotoxin : < 1 EU/μg by LAL
Purity : > 90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 1 mg/mL by BCA
Storage Buffer : Sterile PBS, pH 7.4
Publication :
Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy (2020)
Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack (2022)
Gene Name : KRT19 keratin 19 [ Homo sapiens ]
Official Symbol : KRT19
Synonyms : KRT19; keratin 19; keratin, type I cytoskeletal 19; 40 kDa keratin intermediate filament; CK19; cytokeratin 19; K1CS; K19; keratin; type I cytoskeletal 19; type I; 40 kd; MGC15366; CK-19; keratin-19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament;
Gene ID : 3880
mRNA Refseq : NM_002276
Protein Refseq : NP_002267
MIM : 148020
UniProt ID : P08727

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials involving KRT19 protein? 09/29/2022

Yes, there are ongoing clinical trials exploring the use of KRT19 as a biomarker and its potential as a therapeutic target in cancer treatment.

Are there any non-cancer clinical applications of KRT19? 11/10/2020

Yes, KRT19 can also be used as a biomarker in other diseases, such as liver diseases and rheumatoid arthritis.

Are there any targeted therapies based on KRT19 expression? 11/27/2019

Some targeted therapies are being developed that specifically target cancer cells with high KRT19 expression.

Can KRT19 protein be used to predict the prognosis of cancer patients? 01/25/2019

Yes, KRT19 expression levels can provide information about the prognosis of cancer patients, helping in treatment planning.

How is KRT19 protein detected in clinical samples? 04/23/2016

KRT19 protein can be detected using various laboratory techniques, including immunohistochemistry, ELISA, and PCR.

Customer Reviews (3)

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08/25/2021

    Such support helps researchers overcome challenges and obtain reliable results.

    11/22/2020

      This flexibility allows researchers to focus on specific aspects of KRT19 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

      08/26/2020

        Manufacturers might offer customization options, such as different variants or modifications of the KRT19 protein, to cater to specific research requirements.

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