Recombinant Human HEXA, His-tagged
Cat.No. : | HEXA-7241H |
- Specification
- Gene Information
- Related Products
product overview : | Recombinant human HEXA protein, fused to His-tag at N-terminus, was expressed in E.coli. |
description : | HEXA is the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). |
source : | E. coli |
species : | Human |
tag : | His |
form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol |
molecular mass : | 52.9 kDa (464aa) |
protein length : | 89-529aa |
aa sequence : | MGSSHHHHHH SSGLVPRGSH MGSTLEKNVL VVSVVTPGCN QLPTLESVEN YTLTINDDQC LLLSETVWGA LRGLETFSQL VWKSAEGTFFINKTEIEDFP RFPHRGLLLD TSRHYLPLSS ILDTLDVMAY NKLNVFHWHL VDDPSFPYES FTFPELMRKG SYNPVTHIYT AQDVKEVIEY ARLRGIRVLA EFDTPGHTLS WGPGIPGLLT PCYSGSEPSG TFGPVNPSLN NTYEFMSTFF LEVSSVFPDF YLHLGGDEVD FTCWKSNPEIQDFMRKKGFG EDFKQLESFY IQTLLDIVSS YGKGYVVWQE VFDNKVKIQP DTIIQVWRED IPVNYMKELE LVTKAGFRAL LSAPWYLNRI SYGPDWKDFY VVEPLAFEGT PEQKALVIGG EACMWGEYVD NTNLVPRLWP RAGAVAERLW SNKLTSDLTF AYERLSHFRC ELLRRGVQAQPLNVGFCEQE FEQT |
purity : | >85% by SDS - PAGE |
applications : | SDS-PAGE |
storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
concentration : | 1 mg/ml |
gene name : | HEXA hexosaminidase A (alpha polypeptide) [ Homo sapiens ] |
official symbol : | HEXA |
synonyms : | HEXA; hexosaminidase A (alpha polypeptide); beta-hexosaminidase subunit alpha; GM2 gangliosidosis; Tay Sachs disease; hexosaminidase subunit A; beta-N-acetylhexosaminidase subunit alpha; N-acetyl-beta-glucosaminidase subunit alpha; TSD; MGC99608; |
Gene ID : | 3073 |
mrna refseq : | NM_000520 |
protein refseq : | NP_000511 |
mim : | 606869 |
uniprot id : | P06865 |
chromosome location : | 15q24.1 |
pathway : | Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Glycosphingolipid biosynthesis - ganglio series, organism-specific biosystem; Glycosphingolipid biosynthesis - ganglio series, conserved biosystem; Glycosphingolipid biosynthesis - globo series, organism-specific biosystem; |
function : | beta-N-acetylhexosaminidase activity; cation binding; hydrolase activity, hydrolyzing O-glycosyl compounds; protein heterodimerization activity; |
Products Types
◆ Recombinant Protein | ||
HEXA-4138M | Recombinant Mouse HEXA Protein, His (Fc)-Avi-tagged | +Inquiry |
Hexa-1116M | Recombinant Mouse Hexa Protein, MYC/DDK-tagged | +Inquiry |
HEXA-1890R | Recombinant Rhesus Macaque HEXA Protein, His (Fc)-Avi-tagged | +Inquiry |
HEXA-1087H | Recombinant Human HEXA Protein, MYC/DDK-tagged | +Inquiry |
HEXA-2488R | Recombinant Rat HEXA Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HEXA-548HCL | Recombinant Human HEXA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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