Recombinant Human MAVS, His-tagged

• Cat.No.: MAVS-7247H

Specification

• product overview: Recombinant human MAVS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• description: Mitochondrial antiviral signaling protein, also known as MAVS, is required for innate immune defense against viruses. This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity.
• source: E. coli
• species: Human
• tag: His
• form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• molecular mass: 55.9 kDa (536aa)
• protein length: 1-513aa
• aa sequence: MGSSHHHHHH SSGLVPRGSH MGSMPFAEDK TYKYICRNFS NFCNVDVVEI LPYLPCLTAR DQDRLRATCT LSGNRDTLWH LFNTLQRRPG WVEYFIAALR GCELVDLADE VASVYQSYQP RTSDRPPDPL EPPSLPAERP GPPTPAAAHS IPYNSCREKE PSYPMPVQET QAPESPGENS EQALQTLSPR AIPRNPDGGP LESSSDLAAL SPLTSSGHQE QDTELGSTHT AGATSSLTPS RGPVSPSVSF QPLARSTPRA SRLPGPTGSV VSTGTSFSSS SPGLASAGAA EGKQGAESDQ AEPIICSSGA EAPANSLPSK VPTTLMPVNT VALKVPANPA SVSTVPSKLP TSSKPPGAVP SNALTNPAPS KLPINSTRAG MVPSKVPTSM VLTKVSASTV PTDGSSRNEE TPAAPTPAGA TGGSSAWLDS SSENRGLGSE LSKPGVLASQ VDSPFSGCFE DLAISASTSL GMGPCHGPEE NEYKSEGTFG IHVAENPSIQ LLEGNPGPPA DPDGGPRPQA DRKFQEREVP CHRPSP
• purity: >85% by SDS - PAGE
• applications: SDS-PAGE
• storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• concentration: 0.25 mg/ml
• Publication:
  Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry (2013)

Gene Information

• gene name: MAVS mitochondrial antiviral signaling protein [ Homo sapiens ]
• official symbol: MAVS
• synonyms: MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; CARD adaptor inducing IFN beta; Cardif; IFN B promoter stimulator 1; IPS 1; KIAA1271; virus induced signaling adaptor; VISA; IFN-B promoter stimulator 1; CARD adaptor inducing IFN-beta; virus-induced signaling adaptor; virus-induced-signaling adapter; CARD adapter inducing interferon beta; putative NF-kappa-B-activating protein 031N; interferon beta promoter stimulator protein 1; IPS1; IPS-1; CARDIF; MGC3260; FLJ27482; FLJ31698; FLJ35386; FLJ38051; FLJ41962; DKFZp547C224; DKFZp666M015
• Gene ID: 57506
• mrna refseq: NM_001206491
• protein refseq: NP_001193420
• mim: 609676
• uniprot id: Q7Z434
• chromosome location: 20p13
• pathway: Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem
• function: CARD domain binding; protein binding; protein kinase binding; signal transducer activity