Recombinant Human UBE2D2, His-tagged
Cat.No. : | UBE2D2-71H |
Product Overview : | Recombinant human UBE2D2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-147 aa). |
- Specification
- Gene Information
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Cat. No. : | UBE2D2-71H |
Description : | UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 catalyzes ubiquitination of IkB-alpha in a phosphorylation and SCFB-TRCP dependent manner. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl. |
Molecular Weight : | 18.9 kDa (167aa), confirmed by MALDI-TOF |
Purity : | > 95 % by SDS - PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [ Homo sapiens ] |
Official Symbol : | UBE2D2 |
Synonyms : | UBE2D2; UBC4; PUBC1; UBC4/5; UBCH5B; E2(17)KB2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 D2 OTTHUMP00000223475 OTTHUMP00000223476 OTTHUMP00000223477 OTTHUMP00000223478 OTTHUMP00000224375 ubiquitin-protein ligase D2 ubiquitin carrier protein D2 ubiquitin-conjugating enzyme E2(17)KB 2 ubiquitin-conjugating enzyme E2-17 kDa 2 ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); EC 6.3.2.19; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; Ubiquitin-conjugating enzyme E2 D2 |
Gene ID : | 7322 |
mRNA Refseq : | NM_003339 |
Protein Refseq : | NP_003330 |
MIM : | 602962 |
UniProt ID : | P62837 |
Chromosome Location : | 5q31.2 |
Function : | ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; ubiquitin-protein ligase activity |
Products Types
◆ Recombinant Protein | ||
UBE2D2-243H | Recombinant Human UBE2D2 Protein, His-tagged | +Inquiry |
UBE2D2-67H | Recombinant Human UBE2D2 Protein | +Inquiry |
UBE2D2-6052R | Recombinant Rat UBE2D2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ube2d2-236X | Recombinant Xenopus ube2d2, His-tagged | +Inquiry |
UBE2D2-301587H | Recombinant Human UBE2D2 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
UBE2D2-587HCL | Recombinant Human UBE2D2 293 Cell Lysate | +Inquiry |
UBE2D2-588HCL | Recombinant Human UBE2D2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionUBE2D2 works in tandem with other ubiquitin-proteasome system components, orchestrating protein degradation.
It facilitates the attachment of ubiquitin to target proteins, directing them to the proteasome for breakdown.
UBE2D2 plays a role in controlling the cell cycle by regulating the degradation of key cycle-related proteins.
Targeting UBE2D2 could offer new treatments for conditions involving protein misfolding and aggregation.
Altered UBE2D2 activity is linked with several diseases, including cancer and neurodegenerative disorders.
Genetic mutations in UBE2D2 can disrupt protein turnover, affecting various cellular functions and stability.
UBE2D2, a ubiquitin-conjugating enzyme, is vital for tagging proteins with ubiquitin, marking them for degradation.
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