| Cat. No. : |
CFHR1-269H |
| Description : |
FHR1 (Complement Factor H-related protein 1) is a 43 kDa, secreted member of the factor H family of glycoproteins. The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. FHR1 is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids (aa) in length. It contains five, approximately 60 aa SCRs that basically constitute the entire molecule. FHR1 may play a role in complement regulation, lipid metabolism and lipoprotein complexes that bind PMNs to LPS. |
| Source : |
Mmmalian cells |
| Molecular Mass : |
43 kDa |
| Formulation : |
Lyophilized from a 0.2μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| Purity : |
Greater than 95% as determined by SEC-HPLC and SDS-PAGE. |
| Endotoxin : |
Less than 0.1 ng/μg (1 IEU/μg) |
| Reconstitution : |
We recommend a quick spin followed by reconstitution of Recombinant Human CFHR1 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to working solutions. |
| Storage : |
Lyophilized Complement Factor H-related 1/CFHR1 should be stored at less than -20°C, though stable at room temperature for 3 weeks. Aliquots of reconstituted samples are stable at less than -20°C for 3 months. |
| OfficialSymbol : |
CFHR1 |
