Mouse Anti-LTBR Monoclonal Antibody

• Cat.No.: DMABT-H19157
• Product Overview: Mouse Anti-LTBR Monoclonal Antibody

Specification

• Antigen Description: LT-betaR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member4is a 47 kD transmembrane protein containing4TNF receptor domains. The LT-betaR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTalpha and LTbeta as well as LIGHT. LT-betaR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-betaR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-betaR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-betaR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.
• Target: LTBR
• Immunogen: Human LT-beta R Fc protein
• Host: Mouse
• Isotype: IgG2b, kappa
• species: Human
• Clone: 42H5E9
• Conjugation: N/A
• Applications: Flow Cyt,WB,IP
• Preparation: The LEAF (Low Endotoxin, Azide-Free) antibody was Purified by affinity chromatography.
• Usage recommendation: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤2.0 μg per million cells in 100 μl volume. It is recommended that the reagent be titrated for optimal performance for each application.
• Concentration: 1.0 mg/ml
• Storage: The antibody solution should be stored undiluted at 4 °C. This LEAF solution contains no preservative; handle under aseptic conditions.
• Size: 500 μg

Gene Information

• Gene Name: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ]
• Official Symbol: LTBR
• Synonyms: LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III
• Gene ID: 4055
• mRNA Refseq: NM_002342
• Protein Refseq: NP_002333
• MIM: 600979
• UniProt ID: P36941
• Chromosome Location: 12p13
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
• Function: identical protein binding; protein binding; receptor activity