Recombinant Human KCTD11, His-tagged

• Cat.No.: KCTD11-7539H
• Product Overview: Recombinant human KCTD11 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Antigen Description: BTB/POZ domain-containing protein KCTD11, is a 232 amino acid regulator of neuronal differentiation that induces growth arrest, apoptosis and the expression of p27, a cyclin-dependent kinase inhibitor. Expressed at highest levels in cerebellum, KCTD11 functions as an antagonist of the Hedgehog pathway and activator of the caspase cascade.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 28 kDa (252aa)
• Protein length: 1-232aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: KCTD11 potassium channel tetramerisation domain containing 11 [ Homo sapiens ]
• Official Symbol: KCTD11
• Synonyms: KCTD11; potassium channel tetramerisation domain containing 11; C17orf36, chromosome 17 open reading frame 36; BTB/POZ domain-containing protein KCTD11; KCASH1; REN; retinoic acid, EGF, NGF induced gene protein; potassium channel tetramerization domain containing 11; retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11; C17orf36; REN/KCTD11; MGC129844
• Gene ID: 147040
• mRNA Refseq: NM_001002914
• Protein Refseq: NP_001002914
• MIM: 609848
• UniProt ID: Q693B1
• Chromosome Location: 17p13.2
• Function: voltage-gated potassium channel activity