Recombinant Human NCEH1, His-tagged

• Cat.No.: NCEH1-7558H
• Product Overview: Recombinant human NCEH1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Antigen Description: Neutral cholesterol ester hydrolase 1, also known as NCEH1, hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. It may be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also NCEH1 is involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. This protein may contribute to cancer pathogenesis by promoting tumor cell migration.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 33.6 kDa (298aa)
• Protein length: 1-275aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAEELNA VIVSIEYRLV PKVYFPEQIH DVVRATKYFL KPEVLQKYMV DPGRICISGD SAGGNLAAAL GQQFTQDASL KNKLKLQALI YPVLQALDFN TPSYQQNVNT PILPRYVMVK YWVDYFKGNY DFVQAMIVNN HTSLDVEEAA AVRARLNWTS LLPASFTKNY KPVVQTTGNA RIVQELPQLL DARSAPLIAD QAVLQLLPKT YILTCEHDVL RDDGIMYAKR LESAGVEVTL DHFEDGFHGC MIFTSWPTNF SVGIRTRNSY IKWLDQNL
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: NCEH1 neutral cholesterol ester hydrolase 1 [ Homo sapiens ]
• Official Symbol: NCEH1
• Synonyms: NCEH1; neutral cholesterol ester hydrolase 1; AADACL1, arylacetamide deacetylase like 1; KIAA1363; NCEH; arylacetamide deacetylase-like 1; AADACL1
• Gene ID: 57552
• mRNA Refseq: NM_001146276
• Protein Refseq: NP_001139748
• MIM: 613234
• UniProt ID: Q6PIU2
• Chromosome Location: 3q26.31
• Pathway: Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem
• Function: carboxylesterase activity; hydrolase activity