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Recombinant Human PAH, GST-tagged

Cat.No. : PAH-469H
Product Overview : Recombinant Human PAH (1 a.a. - 452 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ.
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  • Gene Information
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Cat. No. : PAH-469H
Description : PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria.
Source : Wheat germ
Molecular Mass : 78.2 kDa
Sequence : MSTAVLENPGLGRKLSDFGQETSYI EDNCNQNGAISLIFSLKEEVGALAK VLRLFEENDVNLTHIESRPSRL KKDEYEFFTHLDKRSLPALTNIIKI LRHDIGATVHELSRDKKKDTVPWFP RTIQELDRFANQILSYGAELDAD HPGFKDPVYRARRKQFADIAYNYRH GQPIPRVEYMEEGKKTWGTVFKTLK SLYKTHACYEYNHIFPLLEKYC GFHEDNIPQLEDVSQFLQTCTGFRL RPVAGLLSSRDFLGGLAFRVFHCTQ YIRHGSKPMYTPEPDICHELL GHVPLFSDRSFAQFSQEIGLASLGA PDEYIEKLATIYWFTVEFGLCKQGD SIKAYGAGLLSSFGELQYCLSEK PKLLPLELEKTAIQNYTVTEFQPLY YVAESFNDAKEKVRNFAATIPRPFS VRYDPYTQRIEVLDNTQQLKILAD SINSEIGILCSALQKIK
Purification : Glutathione Sepharose 4 Fast Flow
Storage buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Applications : ELISA; WB
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
OfficialSymbol : PAH
Gene Name : PAH phenylalanine hydroxylase [ Homo sapiens ]
Synonyms : PAH; PH; PKU1; PKU; phenylalanine hydroxylase; phenylalanine-4-hydroxylase; phe-4-monooxygenase; phenylalanine 4-monooxygenase; Phe-4-monooxygenase; EC 1.14.16
Gene ID : 5053
mRNA Refseq : NM_000277
Protein Refseq : NP_000268
MIM : 612349
UniProt ID : P00439
Chromosome Location : 12q22-q24.2
Pathway : Abnormal metabolism in phenylketonuria; Biogenic Amine Synthesis; Disease; Metabolism; Metabolism of amino acids and derivatives
Function : amino acid binding cofactor binding; iron ion binding; phenylalanine 4-monooxygenase activity; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PAH be treated with medications? 05/09/2022

Yes, several medications are available to manage the symptoms and slow the progression of PAH.

How can a better understanding of PAH proteins benefit patients with PAH? 01/17/2022

Understanding the role of proteins in PAH can lead to the development of more targeted and effective treatments, improving the quality of life for patients with PAH.

Are there specific biomarkers related to PAH that involve protein expression? 11/27/2021

Yes, certain biomarkers, such as brain natriuretic peptide (BNP) and endothelin-1, can be indicative of PAH.

Are there any protein-targeted therapies for PAH? 10/25/2020

Research is ongoing in the development of protein-targeted therapies for PAH, but no specific protein-targeted drugs are widely used as of my last update in January 2022.

How can proteins be used in the diagnosis and prognosis of PAH? 05/01/2019

Protein biomarkers can help in early diagnosis, and monitoring their levels can aid in assessing disease progression and response to treatment.

Customer Reviews (3)

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Reviews
06/20/2022

    I highly recommend the use of the PAH protein in various experimental applications.

    03/23/2022

      Considering its outstanding performance across multiple assays, I confidently endorse the inclusion of the PAH protein in diverse research studies.

      12/27/2021

        the PAH protein has been successfully utilized in protein electron microscopy structure analysis, providing valuable insights into molecular structures and interactions.

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