Recombinant Human PAH, GST-tagged
Cat.No. : | PAH-469H |
Product Overview : | Recombinant Human PAH (1 a.a. - 452 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PAH-469H |
Description : | PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. |
Source : | Wheat germ |
Molecular Mass : | 78.2 kDa |
Sequence : | MSTAVLENPGLGRKLSDFGQETSYI EDNCNQNGAISLIFSLKEEVGALAK VLRLFEENDVNLTHIESRPSRL KKDEYEFFTHLDKRSLPALTNIIKI LRHDIGATVHELSRDKKKDTVPWFP RTIQELDRFANQILSYGAELDAD HPGFKDPVYRARRKQFADIAYNYRH GQPIPRVEYMEEGKKTWGTVFKTLK SLYKTHACYEYNHIFPLLEKYC GFHEDNIPQLEDVSQFLQTCTGFRL RPVAGLLSSRDFLGGLAFRVFHCTQ YIRHGSKPMYTPEPDICHELL GHVPLFSDRSFAQFSQEIGLASLGA PDEYIEKLATIYWFTVEFGLCKQGD SIKAYGAGLLSSFGELQYCLSEK PKLLPLELEKTAIQNYTVTEFQPLY YVAESFNDAKEKVRNFAATIPRPFS VRYDPYTQRIEVLDNTQQLKILAD SINSEIGILCSALQKIK |
Purification : | Glutathione Sepharose 4 Fast Flow |
Storage buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer. |
Applications : | ELISA; WB |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
OfficialSymbol : | PAH |
Gene Name : | PAH phenylalanine hydroxylase [ Homo sapiens ] |
Synonyms : | PAH; PH; PKU1; PKU; phenylalanine hydroxylase; phenylalanine-4-hydroxylase; phe-4-monooxygenase; phenylalanine 4-monooxygenase; Phe-4-monooxygenase; EC 1.14.16 |
Gene ID : | 5053 |
mRNA Refseq : | NM_000277 |
Protein Refseq : | NP_000268 |
MIM : | 612349 |
UniProt ID : | P00439 |
Chromosome Location : | 12q22-q24.2 |
Pathway : | Abnormal metabolism in phenylketonuria; Biogenic Amine Synthesis; Disease; Metabolism; Metabolism of amino acids and derivatives |
Function : | amino acid binding cofactor binding; iron ion binding; phenylalanine 4-monooxygenase activity; protein homodimerization activity |
Products Types
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◆ Lysates | ||
PAH-461HCL | Recombinant Human PAH cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0647 | p-Aminohippuric Acid Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several medications are available to manage the symptoms and slow the progression of PAH.
Understanding the role of proteins in PAH can lead to the development of more targeted and effective treatments, improving the quality of life for patients with PAH.
Yes, certain biomarkers, such as brain natriuretic peptide (BNP) and endothelin-1, can be indicative of PAH.
Research is ongoing in the development of protein-targeted therapies for PAH, but no specific protein-targeted drugs are widely used as of my last update in January 2022.
Protein biomarkers can help in early diagnosis, and monitoring their levels can aid in assessing disease progression and response to treatment.
Customer Reviews (3)
Write a reviewI highly recommend the use of the PAH protein in various experimental applications.
Considering its outstanding performance across multiple assays, I confidently endorse the inclusion of the PAH protein in diverse research studies.
the PAH protein has been successfully utilized in protein electron microscopy structure analysis, providing valuable insights into molecular structures and interactions.
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