"C1QA" Related Products

Expand
Expand
Expand

Recombinant Human Complement Component 1, q Subcomponent, A Chain

Cat. No. : C1QA-4292H
Product Overview : Human Complement Component C1q produced in Human plasma having a molecular mass of 410 kDa.
Description : C1q is a glycoprotein that belongs to the collectin family, having a molecular weight of about 410-462 kDa. C1q is a hexamer composed of globular heads attached to collagen-like triple-helix tails. The globular heads of C1q exclusively bind to the CH2 domain of IgG molecules or the CH3 domain of IgM. Each heavy chain of the immunoglobulin molecule contains a single binding site for C1q. Given that C1q must bind to no less than two heavy chains in order to alter its conformation and activate C1r and C1s, its activation follows only after binding to immunoglobulins in the form of immune complexes bound to multivalent antigens. C1q's main physiological role is in the clearance of immune complexes and apoptotic bodies from the organism. Interruption of this process may lead to development of autoimmunity. Individuals with genetic deficiencies of C1q or other components of the classical pathway are at risk to develop SLE. C1q specifically binds to apoptotic bodies of human keratinocytes, vascular endothelial cells and lymphocytes. Complement components C1q and bound C3 mediate the clearance of apoptotic bodies. Hence, C1q may advance the clearance of autoantigens, avoiding stimulation of the immune system. Nonetheless, an extended exposition of the immune system to the neoepitope exposed on C1q molecules bound to immune complexes or apoptotic bodies could ultimately lead to an autoimmune response against C1q itself and to an altered complement function. C1q deficiency may also lead to disruption of the negative selection of autoreactive B cells. C1q along with other specific recognition proteins bind to the highly conserved lupus antigens (dsDNA and nuclear proteins) and activate the complement system. Autoantibodies against C1q (anti-C1q) are found in a number of autoimmune and infectious diseases like glomerulonephritis (GN) and lupus erythematosus (SLE), these antibodies are significant in clinical practice due to their negative predictive value.
Source : Human
Host : Escherichia Coli.
Form : Lyophilized from 0.01M Na2 EDTA solution containing 0.3M NaCl pH 7.5.
Purity : Greater than 96.0%.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized C1q in sterile 18MΩ-cm H2O.
Storage : Human C1q although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Gene Name : C1QA complement component 1, q subcomponent, A chain [ Homo sapiens ]
Official Symbol : C1QA
Synonyms : C1QA; complement component 1, q subcomponent, A chain; complement C1q subcomponent subunit A; OTTHUMP00000002936; complement component C1q, A chain; complement component 1, q subcomponent, alpha polypeptide; Complement C1q subcomponent subunit A; OTTHUMP00000197085; OTTHUMP00000037919
Gene ID : 712
mRNA Refseq : NM_015991
Protein Refseq : NP_057075
MIM : 120550
UniProt ID : P02745
Chromosome Location : 1p36.12
Pathway : Chagas disease (American trypanosomiasis); Classical antibody-mediated complement activation; Complement and Coagulation Cascades; Complement and coagulation cascades; Initial triggering of complement; Systemic lupus erythematosus

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.