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Recombinant Human C5

Cat.No. : C5-4756H
Product Overview : Recombinant human Complement Component C5a (rhC5a) Leu679-Arg751 was produced in E.coli cells.
Description : The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
Source : E. Coli
Species : Human
Form : Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Bio-activity : rhC5a is active based on enzyme release assay of myeloperoxidase. The ED50 = 1.36 nM.
Molecular Mass : rhC5a has a calculated MW of 8.3 kDa. DTT-reduced protein migrates as estimated 8.3 kDa polypeptide in SDS-PAGE.
Endotoxin : Less than 1.0 EU per 1 μg of the rhC5a by the LAL method.
Purity : >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).
Gene Name : C5 complement component 5 [ Homo sapiens (human) ]
Official Symbol : C5
Synonyms : C5; C5a; C5b; CPAMD4; complement component 5; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Gene ID : 727
mRNA Refseq : NM_001735
Protein Refseq : NP_001726
MIM : 120900
UniProt ID : P01031
Chromosome Location : 9q33-q34
Pathway : Activation of C3 and C5; Complement Activation, Classical Pathway; Herpes simplex infection
Function : C5a anaphylatoxin chemotactic receptor binding; endopeptidase inhibitor activity; protein binding

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