Active Recombinant Human INHBA, His-tagged
Cat.No. : | INHBA-173H |
Product Overview : | Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids and having a molecular weight of 27.4kDa. The Active form Activin-A is fused to a 6-His tag at N-terminus and purified by standard chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. |
Source : | Nicotiana benthamiana. |
Species : | Human |
Tag : | His |
Form : | Lyophilized freeze dried powder. Active form Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 50mM Tris-HCl pH-7.4. |
Bio-activity : | The biological activity of INHBA is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation ([3H]thymidine incorporation). ED50<5ng/ml. |
AA Sequence : | HHHHHHGLECDGKVNICCKKQFFVS FKDIGWNDWIIAPSGYHANYCEGEC PSHIAGTSGSSLSFHSTVINHYRMR GHSPFANLKSCCVPTKLRPMSMLYY DDGQNIIKKDIQNMIVEECGCS. |
Purity : | Greater than 98% as obsereved by SDS-PAGE. |
Stability : | For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended. |
Reconstitution : | INHBA protein should be reconstituted in distilled water to a concentration of 50 ug /ml. Due to the protein nature, dimmers and multimers may be observed. |
Gene Name : | INHBA inhibin, beta A [ Homo sapiens (human) ] |
Official Symbol : | INHBA |
Synonyms : | INHBA; EDF; FRP; inhibin, beta A; inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide) |
Gene ID : | 3624 |
mRNA Refseq : | NM_002192 |
Protein Refseq : | NP_002183 |
MIM : | 147290 |
UniProt ID : | P08476 |
Chromosome Location : | 7p15-p13 |
Pathway : | ALK1 signaling events; Antagonism of Activin by Follistatin; Cardiac Progenitor Differentiation |
Function : | cytokine activity; growth factor activity; hormone activity |
Products Types
◆ Recombinant Protein | ||
INHBA-552H | Recombinant Human INHBA Protein | +Inquiry |
INHBA-02H | Active Recombinant Human INHBA Protein, Animal Free | +Inquiry |
INHBA-184H | Active Recombinant Human INHBA Protein (Gly311-Ser426), Animal-free, Carrier-free | +Inquiry |
INHBA-194H | Active Recombinant Human/Mouse/Rat INHBA Protein | +Inquiry |
INHBA-2721R | Recombinant Rat INHBA Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
INHBA-2078MCL | Recombinant Mouse INHBA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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