"INHBA" Related Products

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Recombinant Human INHBA, His-tagged

Cat.No. : INHBA-173H
Product Overview : Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids and having a molecular weight of 27.4kDa. The Active form Activin-A is fused to a 6-His tag at N-terminus and purified by standard chromatographic techniques.
Description : The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Source : Nicotiana benthamiana.
Species : Human
Tag : His
Form : Lyophilized freeze dried powder. Active form Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 50mM Tris-HCl pH-7.4.
Bio-activity : The biological activity of INHBA is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation ([3H]thymidine incorporation). ED50<5ng/ml.
AA Sequence : HHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS.
Purity : Greater than 98% as obsereved by SDS-PAGE.
Stability : For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.
Reconstitution : INHBA protein should be reconstituted in distilled water to a concentration of 50 ug /ml. Due to the protein nature, dimmers and multimers may be observed.
Gene Name : INHBA inhibin, beta A [ Homo sapiens (human) ]
Official Symbol : INHBA
Synonyms : INHBA; EDF; FRP; inhibin, beta A; inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide)
Gene ID : 3624
mRNA Refseq : NM_002192
Protein Refseq : NP_002183
MIM : 147290
UniProt ID : P08476
Chromosome Location : 7p15-p13
Pathway : ALK1 signaling events; Antagonism of Activin by Follistatin; Cardiac Progenitor Differentiation
Function : cytokine activity; growth factor activity; hormone activity

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